Elena Borodina, Russian Federation
Saint Petersburg State University, The Laboratory of the Mosaic of Autoimmunity Department of Obstetrics, Gynecology and Reproductive Sciences,Presenter of 1 Presentation
THE PATHOGENIC ROLE OF CIRCULATING HASHIMOTO'S THYROIDITIS-DERIVED TPO POSITIVE IGG ON FETAL DEVELOPMENT IN NAÏVE MICE: RESULTS OF PRELIMINARY STUDY
Session Name
Session Type
PARALLEL SESSIONS
Date
31.05.2021, Monday
Session Time
10:00 - 12:00
Room
HALL A
Lecture Time
11:20 - 11:30
Presenter
Abstract
Background and Aims
Antibody-mediated-autoimmune-diseases such as autoimmune thyroid diseases (ATD), systemic-lupus-erythematosus (SLE) and antiphospholipid-syndrome (APS), often are associated with abnormalities of fetal development and recurrent fetal loss. One of the ATD is Hashimoto's thyroiditis which recently showed association with complications of pregnancy with increased levels of circulating autoantibodies reactive with epitopes on thyroid tissue such as thyroid peroxidase (aTPO). In retrospective study of sera analyses in patients with Hashimoto's thyroiditis, all patients had elevated circulating aTPO autoantibodies, whereas about 50% of patients with circulating autoantibodies targeting thyroglobulin or thyroid stimulating hormone antibodies (anti-TSH).We assessed the potential of human anti-TPO highly positive IgG, derived from patients with Hashimoto's thyroiditis sera, to cause directly complications of pregnancy in murine experimental model.