Paola Triggianese, Italy
Rheumatology, Allergy and Clinical Immunology, University of Rome Tor Vergata Department of “Medicina dei Sistemi”Presenter of 1 Presentation
HUMAN LEUKOCYTE ANTIGEN (HLA) TYPING STUDY IDENTIFIES THE PREVALENCE OF MATERNAL DQ2 SUSCEPTIBILITY ALLELES AMONG INFERTILE WOMEN: POTENTIAL ASSOCIATIONS WITH MICRONUTRIENTS DEFICIENCY AND AUTOIMMUNITY
Abstract
Background and Aims
Obsteric Antiphospholipid Syndrome (OAPS) is the most frequently treatable acquired cause of thrombosis and placental dysfunction during pregnancy. In women carrying antiphospholipid antibodies (aPL), it is possible to find an inherited thrombophilic disorder (ITP). However, the association between obstetrical complications and ITP in OAPS women is still debated. We aimed to evaluate ITP and clinical features from a cohort of OAPS women in order to explore foetal-maternal outcomes according to laboratory categories.
Methods
In this study, we analyzed data from a monocentric cohort of Caucasian women who fullfilled the Sydney Criteria of APS. All thrombotic events, obstetrical complications, and concomitant autoimmune disorders were documented. Laboratory data included common ITP (protein C, protein S, FV Leiden and FII G20210A mutations), and autoantibodies (aPL, antibodies of connective tissue disease - CTD, and anti-thyroid autoantibodies).
Results
All of women were in the fertility age at APS diagnosis. Most of them were non-smokers and with normal body mass index. ITP were registered in 15% of women cohort. CTD-associated antibodies were found in 30% of women while thyroid autoimmunity was revealed in 20%. Live-birth was achieved in 80% of the cohort. The most prevalent obstetrical complications were recurrent miscarriage (50%) and preterm delivery <37 w (10%).
Conclusions
Our findings indicate that relevant associations can occur between laboratory categories and pregnancy outcomes in OAPS women.