Background and Aims

Several studies showed the difference in incidence of T1DM depending on the place of living. Much more children suffering from immunopathological diseases were urban residents. Based on above mentioned background we compared the regional distribution of the T1DM incidence in correlation to several urbanization-related factors.

Objective: identify urbanization-related factors affecting the incidence and prevalence of T1DM in children 0-14 years in RF.

Methods

The subject of the analysis was the incidence of T1DM “Children 0-14 years” group per 100 000 populations the period from 2008 to 2019.

Since among the classic urbanization-related factors are the indicators of air/water pollution, geographical density of public roads, number of public buses. Descriptive statistics included the Mean; Median [Q1; Q3]; and indications of the min-max values.We searched for the optimal models using the lowest value of the Akaike’s criterion.

Results

A significant multiplicative effect of the roads density, number of buses and air pollution on the incidence of T1DM was found. The number of buses and the paved roads geographic density have a multiplicative statistically reliable effect, and at the same time there is an independent effect of air pollution on the the incidence of T1DM (p>0.05).

Conclusions

The identified urbanization-related factors reliably contribute to the development and distribution of type I diabetes.

The main urban environmental factor contributing to the T1DM incidence confirmed during mathematical modeling is air pollution with solid dust particles, namely air emissions from the stationary sources, and impact of geographic density of hard-paved roads and the number of public buses.