VARIABILITY OF CLINICAL CHARACTERISTICS AND OUTCOMES OF PATIENTS WITH ANCA-ASSOCIATED VASCULITIDES IN A LATIN-AMERICAN HOSPITAL
- Gabriel J. Tobón, Colombia
Abstract
Background and Aims
ANCA-associated vasculitis (AAV) are necrotizing vasculitis, predominantly affecting small vessels, and associated with ANCA specific for myeloperoxidase (MPO-ANCA) or proteinase 3 (PR3-ANCA), with a very varied clinical spectrum. This study aimed to describe the clinical characteristics of patients with ANCA-associated vasculitis (AAV) in the first disease presentation and the ultimate clinical control. Besides to determine serological characteristics, treatment, and outcomes.
Methods
A total of 68 patients with AAV diagnosed between January 2011 and June 2019, in a high-complexity Hospital in Cali - Colombia was retrospectively analyzed. The activity was established using the Birmingham Vasculitis Activity Score (BVAS).
Results
Altogether, 60.2% had granulomatosis with polyangiitis (GPA), 19.1% microscopic polyangiitis (MPA), and 17,6% eosinophilic granulomatosis with polyangiitis (EGPA). The mean age at diagnosis was 50,3 ± 15,4 years in GPA, 50,2 ± 14,5 years in MPA, and 49,2 ± 14,7 years in EGPA. Arthralgia and ear-nose-throat (ENT) symptoms were the most common at disease onset (Figure 1). The initial BVAS was 12 (3-18) in GPA patients. Outcomes were variable, 11 patients with end-stage chronic renal failure, and five patients requiring renal transplantation.
Conclusions
The prevalence of AAV and the clinical characteristics in Latin-American patients are unknown; for that reason, these studies are necessaries.