Background and Aims

Anti-DFS70/LEDGFp75 auto-antibodies (Anti-DFS 70 Ab) usually target the dense fine speckled protein of 70kDa (DFS70), commonly known as lens epithelium-derived growth factor p75 (LEDGFp75).

This auto-antigen is thought to be a stress response protein that is ubiquitously expressed in mammalian cells and tissues, with overexpression in cancer cells and tumors such as breast cancer

The aim of our work was to study the frequency of Anti-DFS70 Ab and if they could be a new biomarker in breast cancer.

Methods

Is a prospective descriptive study including 32 patients with a breast cancer in Military Hospital of Tunis

The blood samples and clinical data were collected from all patients. The Serological analyses were performed using Dot Technic EUROIMMUN ^© in the laboratory of immunology. Written informed consent was obtained from all participants

Results

The middle age of patients was 47 years

We found a frequency of 15,63 % of Anti-DFS70 Ab in our breast cancer patients

There was a significant correlation between Anti DFS 70 Ab and the tumor size (p=0.038 <p=0.5).

We have noted also that all patients with lymph node involvement have positive Anti- DFS70 Ab.

Conclusions

Our results suggests that Anti-DFS Ab could be a new biomarker in breast cancer.

A more large study is needed to confirm our results.