PREVALENCE OF LATENT AND OVERT POLYAUTOIMMUNITY IN AUTOIMMUNE THYROID DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS
- Manuel Rojas, Colombia
Abstract
Background and Aims
Thyroid autoimmunity is the most frequent condition involved into polyautoimmunity (PolyA). However, the frequency of latent and overt PolyA in autoimmune thyroid disease (AITD) as index condition is unknown.
Methods
This study adhered to the relevant sections of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline. Searches through MEDLINE, EMBASE, and LILACS were performed to include articles in Spanish and English, and published up to August 8, 2018. Relevant vocabulary terms and key terms related to AITD and other autoimmune diseases were used. Fixed and random effects models were used accordingly.
Results
A total of 46 articles fulfilled inclusion criteria, of which 24 were case-controls, 17 were cohorts, and 5 were cross-sectional studies. These studies included a total of 38,921 patients with a mean age of 32.26 years. Female was the predominant gender including 31,251 patients (81.15%, 95% CI: 80.75-81.54). Graves’ disease was the most common type of AITD (64.72%, 95% CI: 63.45-65.98). Overt PolyA was found in 13.09% of patients (95% CI: 12.5-13.71). This type of PolyA was principally represented by type 1 diabetes (4.36%, 95% CI: 3.84-4.95) and autoimmune gastritis (4.24%, 95% CI: 3.63-4.95) (Figure 1A). Latent PolyA was presented in 17.59% of patients (95% CI: 16.64-18.58), in which anti-nuclear antibodies (23.39%, CI: 7.78-52.50), and anti-proinsulin antibodies (18.64%, 95% CI: 13.57-25.07) were the most common (Figure 1B).
Conclusions
Latent and overt PolyA are common in patients with AITD. These results provide insightful information for early diagnosis and management of concurrent ADs in patients with AITD.