Stefanie Lanzinger, Germany
Ulm University Institute of Epidemiology and Medical Biometry, ZIBMTPresenter of 1 Presentation
TEMPORAL TRENDS IN DIABETES TECHNOLOGY USE AND ASSOCIATED OUTCOMES AMONG CHILDREN WITH TYPE 1 DIABETES ≤6 YEARS BETWEEN 2000 AND 2020
Abstract
Background and Aims
To investigate temporal trends in the use of insulin pumps (CSII) and continuous glucose monitoring (CGM) in children with type 1 diabetes (T1D) ≤6 years of age from 2000 to 2020. Furthermore, to study changes in HbA1c and event rates of severe hypoglycaemia over time in a prospective, multicentre diabetes patient follow-up (DPV) registry.
Methods
Children with T1D ≤6 years (≥ 6 months at onset), registered in DPV from 2000 to 2020 were included. Temporal trends in diabetes technology use were studied using repeated measurements logistic regression models considering sex, diabetes duration (≤1 year, >1 year), age (<2, 2-<4, ≥4 years), migration background and the interaction of age*year as covariates. Changes in HbA1c and event rates of severe hypoglycaemia were studied using linear and negative binomial regression models.
Results
Among 16,907 children, use of CSII increased consistently from 2000 (<1%) to 2020 (86%) with a most significant increase in very young children <2 years (2020: 96% (95%-CI:93-98%) vs 90% (88-92% 2-<4 years), 82% (80-84% 4-≤6 years)). Use of CGM increased from 2% in 2016 to 73% in 2020 (76% (69-81%) <2 years to 72% (70-74%) in 4-≤6 years). HbA1c was stable at 7.7%. Event rates of severe hypoglycaemia decreased significantly from 0.35 events/PY (0.30-0.40PY) in 2000 to 0.07 events/PY (0.06-0.09PY) in 2020.
Conclusions
These registry data show consistent increases in CSII and CGM use in T1D children ≤6 years during the last 2 decades. Increasing use of diabetes technology might be associated with the significant decrease in severe hypoglycaemia.