Oleg Dianov, Russian Federation
Clinical Children’s Hospital No2 EndocrinologyPresenter of 1 Presentation
GLYCEMIA VARIABILITY (VG) IN CHILDREN WITH TD1 ACCORDING TO THE GLYCEMIC PROFILE
Abstract
Background and Aims
We assessed VG according to the glycemic profile data in 126 children with TD1 - amplitude of fluctuations SD, MAGE, CV and their correlation.
Methods
We developed a program which can calculate indicators based on the data of the patient’s glycemic profile. To do this, enter the values from the data in the field and click "calculate indicators". The values of the main VG indicators will appear on the screen. Amplitude of fluctuations in glycemia was 6.7 mmol/l (5.3; 8.7). CV 30.3% (25.9; 36.9) indicates frequent fluctuations in glycemia during the day. Indicator SD 2.62 σ (2.0; 3.28) confirms these changes, because it's connected with CV. MAGE was 4.4 mmol/L (3.5; 6.0), indicating its prevalence. The high correlation was between MAGE and the amplitude of fluctuations r=0.880 (p<0.01), between MAGE and CV r=0.779 (p<0.01), between SD and the amplitude of fluctuations r = 0.965, p<0.01. The correlation coefficient between CV and the amplitude of fluctuations was 0.784 (p<0.01).
Results
Significant fluctuations in glycemia, indicating an unsatisfactory course of the disease in most patients, were found.
Conclusions
All the considered VG indicators had a connection - the CV with all other indicators and the amplitude of fluctuations. An increase in amplitude of fluctuations can be considered with SD and CV as a feature of glycemic instability in the assessment of the patient’s glycemic profile.