Hiroshi Takahashi, Japan
Jikei University School of Medicine Diabetes, Metabolism and EndocrinologyPresenter of 1 Presentation
POPULATION-BASED CROSS-SECTIONAL STUDY OF THE RELATIONSHIP BETWEEN INSULIN RESISTANCE AND FATTY LIVER INDEX IN JAPANESE SCHOOL CHILDREN
Abstract
Background and Aims
Little information is available regarding the relationship between insulin resistance (IR) and fatty liver index (FLI) in children in a population-based setting.
Methods
The study included a total of 56 ninth-grade children participating in check-up programs implemented in Tsunan Town, Niigata, Japan (boys/girls, 32/24). IR was defined as homeostasis model assessment (HOMA)-R ≧2.5. FLI was calculated using waist circumference, BMI, γGTP, TG, and FLI ≧60 was defined as fatty liver. Correlations between these parameters were evaluated using the Spearman’s correlation test.
Results
The medians (25-75thpercentiles) of HOMA of IR , FLI and body mass index in boys were 1.9 (1.3-3.0), 2.7 (1.7-3.9) and 19.3 (18.1-21.4)kg/m2, respectively, vs 2.1 (1.6-4.4), 4.6 (1.9-12.5) and 21.5 (20.0-25.3)kg/m2 in girls, respectively. Those with IR were not significantly different between girls and boys (41.7/28.7%; P=0.254). FLI tended to be higher proportion of girls than boys (8.3/3.1%; P=0.091). The correlation between IR and FLI was significant only in girls but not in boys (r = 0.705; P < 0.001, r = -0.012; P = 0.952).
Conclusions
The correlation between FLI and IR was examined in Japanese school children aged 14 to 15 years old. IR was significantly correlated with FLI in girls. Therefore, IR could be a potential indicator for predicting fatty liver in girls.