Alfonso Galderisi, United States of America

Yale University Pediatrics

Presenter of 1 Presentation

 Conference Calendar

AFREZZA PRE-MEAL BOLUS REDUCES EARLY GLYCEMIC EXCURSION DURING HYBRID CLOSED LOOP TREATMENT

Session Name
ORAL PRESENTATION SESSION 09
Session Type
ORAL PRESENTATION SESSION
Date
22.02.2020, Saturday
Session Time
08:30 - 10:00
Channel
Berlin
Lecture Time
08:30 - 08:40
Presenter
Authors

Abstract

Background and Aims

Background. Optimizing post-prandial glycemic control during closed-loop (CL) treatment remains a challenge given the delays in insulin absorption and action. We aimed to investigate the effect of ultra-fast acting Afrezza inhaled insulin on improving post-prandial blood glucose control during hybrid closed loop (HCL) treatment in young adults with type 1 diabetes.

Methods

Methods: We conducted an inpatient, three-way, randomized crossover meal study to assess the efficacy and safety of Afrezza at a low(AL) and a high dose(AH) as compared to a rapid-acting insulin(RAI) pre-meal bolus during Diabetes-Assistant-HCL treatment. The 11 participants received two sequential meals on three study days with RAI, AH(rounded up available Afrezza dose) or AL(rounded down Afrezza dose). The primary efficacy outcome was the peak postprandial plasma glucose (PPG) level calculated by pooling data for four hours after the start of each meal.

Results

Results: The mean PPG for the RAI control arm and AHwere similar (185±50mg/dL vs. 195±46mg/dL, respectively; p=0.45), while it was higher for meals using AL(208±54mg/dL, p=0.04). The AHachieved significantly lower early PPG level than the RAI arm (30 min; p<0.001), and improvement in PPG waned at 120 and 180 min (p=0.02).abstract figure afrezza shaded 10-2-19.png

Conclusions

Conclusions: Afrezza (AH) pre-meal bolus reduced the early glycemic excursion and improved PPG during HCL compared to RAI pre-meal bolus. The improvement in PPG has not been sustained after the end of Afrezza glucodynamic action at 120m.

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