Yifei Mo, China
Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Department of Endocrinology and MetabolismPresenter of 1 Presentation
DEFINING THE TARGET VALUE OF COEFFICIENT OF VARIATION IN CHINESE DIABETES PATIENTS
Abstract
Background and Aims
To define the target value of coefficient of variation (CV) in Chinese diabetes patients
Methods
A total of 3007 diabetes patients underwent continuous glucose monitoring (CGM). Type 2 diabetes were divided into groups according to the treatment: group 1, non-insulinotropic agent alone (n=138); group 2, oral therapy with insulinotropic agent (n=761); group 3, basal insulin therapy (n=100); group 4, premix insulin (n=784) and group 5, intensive insulin therapy (n=612). Another 612 type 1 diabetes were included as group 6. %CV and time per day within, below and above target glucose range were computed. TBR3.9 ≥4% and TBR3.0 ≥1% were defined as excessive hypoglycemia.
Results
Type 2 diabetes with premixed or intensive insulin regimens had increased %CV than those on oral therapy or basal insulin. The upper limit of %CV in group 1 was 33%, which was adopted as the threshold to define excess glycemic variability. In each group, the percentage of patients with TBR3.9≥4% was significantly greater in subgroup with %CV>33% than ≤33% (P<0.001). In well-controlled patients who had TBR3.9<4%, TIR3.9-10>70% and TAR10<25%, the 95th percentile of %CV was 32.70% (close to 33%). The optimal cutoff values for %CV as identifier of TBR3.9≥4% by ROC analysis were different in groups with different treatment or with different A1C ranges (27% in A1C 6-7% group; 30.1% in A1C 9-10% group and 35.1% in A1C≥10% group)
Conclusions
The target value of %CV seems to be 33% in Chinese diabetes. However, patients with different A1C ranges or different therapy should be considered to use a personized %CV target.