Alena Shyshko, Belarus
Belarusian Medical University Department of endocrinologyPresenter of 1 Presentation
THE EFFICACY OF LIFESTYLE MODIFICATION AND PICOLINATE CHROMIUM INTAKE IN SUBJECTS WITH IMPAIRED GLUCOSE HOMEOSTASIS
Abstract
Background and Aims
The aim of our study is to assess the efficacy of lifestyle modification and picolinate chromium intake in preventing diabetes mellitus type 2 (DM 2)
Methods
The study included 100 patients (69 m 258 f) 25-65 years with impaired glucose tolerance (IGT) and newly diagnosed DM 2. Patients were divided into 2 groups matched by age, weight, body mass index (BMI), waist-to-hip ratio (WHR). Research group included 54 patients who carried out recommendations of a balanced diet, physical activity and picolinate chromium was taken 200mkg per day for 1 month. Control group included 46 patients who did not lifestyle modification. The study was 24 weeks. We measured fasting plasma glycated hemoglobin (HbA1c,%) and related to fasting leptin (FL).
Results
: Patients of the research group demonstrated reduction of BMI (-3.2±2.1 kg/m2) and WHR (-0.02±0.025) (p<0.01 for all) and positive dynamics of HbA1c ( p<0.001). Persons of the control group had increase BMI, WHR as also HbA1c elevation (p<0.05). The main novel finding was that median serum leptin in research group decreased on -23.9% (p<0.01) and increased in control group on +27.6% (p<0.01). Among subjects with IGT from the research group, HbA1c normalized in 49.3% (p<0.001) and serum leptin levels decreased on 26.9% (p<0.01). In control group HbA1c normalized in 4.5% (p<0.01). Among patients of the research group was a reduction of DM 2 by 11.9% and an increase in the control group by 35.1%.
Conclusions
Lifestyle modifications with picolinate chromium intake leads to the restoration of glucose homeostasis and preventing DM 2