Alexander E. Berezin, Ukraine

StateMedical University of Zaporozhye Internal Medicine

Presenter of 1 Presentation

 Conference Calendar

NON-CLASSICAL PHENOTYPES OF CIRCULATING ENDOTHELIAL CELL-DERIVED PROGENITOR CELLS IN ABDOMINAL OBESITY PATIENTS WITH ASYMPTOMATIC CARDIAC DYSFUNCTION

Session Name
NEW TECHNOLOGIES FOR TREATING OBESITY AND PREVENTING RELATED DIABETES
Session Type
E-POSTER VIEWING (EXHIBITION HOURS)
Date
20.02.2020, Thursday
Session Time
09:30 - 15:30
Channel
E-Poster Area
Lecture Time
09:31 - 09:32
Presenter
Authors

Abstract

Background and Aims

Abdominal obesity strongly associates with multiple metabolic abnormalities (dyslipidemia, insulin resistance [IR], increased fasting glucose and impaired glucose tolerance) and higher cardiovascular (CV) risk. The aim of the study: to investigate the number of circulating EPCs in patients with asymptomatic cardiac dysfunction and different phenotypes of obesity.

Methods

The study was retrospectively evolved 46 patients with asymptomatic chromic heart failure (left ventricular ejection fraction 40%-49%) and established abdominal obesity (47 patients with metabolically unhealthy obesity [Met-UHO] and 42 subjects with metabolically healthy obesity [Met-HO]) from the large cohort of dismetabolic patients (n=268). High-Definition Fluorescence Activated Cell Sorter methodology was performed for measurement of the number of circulating endothelial progenitor cells co-expressed CD45, CD34, CD14, CD309, and Tie-2 antigens.

Results

A significant difference between number of circulating progenitor cells labeled CD45-CD34+ and CD14+CD309+ in Met-UHO and Met-HO patients was found. In contrast, Met-UHO patients had a significantly lower level of circulating CD14+ Tie-2+ cells and ะกD309+ Tie-2+cells compared with Met-HO individuals. In multivariate logistic regression analysis we found that HOMA-IR, hs-CRP, and number of CV risk factorswere independent predictors for depletion in numerous of circulating progenitor cells with immune phenotypes CD309/Tie2+ cells and CD14/Tie2+.

Conclusions

We found that the lowered circulating number of CD309/Tie2+ cells / CD14/Tie2+ cells produces the well balanced discrimination on Met-UHO development in Met-HO patients with co-existing preserved left ventricular ejection fraction than other models based on conventional CV risk factors.

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