Olga Derevyanko, Russian Federation
Presenter of 3 Presentations
SOCIAL MEDIA INFLUENCERS GIVE BAD DIET ADVICE FOR DIABETIC PATIENTS.
Abstract
Background and Aims
Diabetes is one of the most challenging chronic health conditions in 21th century. Diabetes-related problems need proper patient education, and social media plays a role to disseminate information. The aim of our study was to evaluate the quality of medical information presented in social network.
Methods
We studied 20 Russians top popular influencers, based on those who had more than 100,000 followers in Instagram social media and who had hashtags #diabetes, #diabetic_nutrition.
Results
We found that 14 out of 20 of the blogs (20%) could not be considered credible sources of diabetes management information. These blogs have unrelieble and potentially harmful recommendations like "fruits are undoubtedly products that lower blood sugar" or such kind of not evidence-based information: “The main savior for diabetics is cinnamon. The combination of polyphenols and magnesium mimics the effects of insulin, making sugar levels drop significantly. Garlic is another very useful supplement that makes the pancreas secrete double-acting insulin.”
Conclusions
Social media influencers blogs are not credible resources for diabetes management. Popularity and impact of social media in the context of the diabetes epidemic suggests all influencers should be required to meet accepted scientifically or medically justified criteria for the provision of diabetes management advice online.
EXOCRINE PANCREATIC AUTOANTIBODIES LEVELS HIGHER IN LONG-STANDING TYPE 1 DIABETES MELLITUS.
Abstract
Background and Aims
IgG4 and Lactoferrin (ALF) autoantibodies (Ab) prevalence in different duration type 1 diabetes mellitus (T1D).
Methods
A total of 78 patients (41 men, 37 women) with T1D were included in the study. Patients were divided in 2 groups, according to T1D duration. All patients underwent an immunological study, which included the determination of IgG4 and ALF Ab.The patients were also examined for pancreatic b-cell Aab, C-peptide, HbA1c. Ab to IgG4, ALF, glutamic acid decarboxylase (GADA), tyrosine phosphatase-like IA-2 (IA-2A) and zinc T8 (ZnT8A) were detected by ELISA.
Results
| T1D groups | a (n=32) | b (n=46) |
|---|---|---|
| Age, years | 22,3 [19,2;25,8] | 29,7 [24,6;39,1] |
| T1D duration, years | 2,7 [0,8;3,9] | 17,6 [14,4;21,3] |
| Fasting C-peptide, ng/ml | 0,86 [0,53;1,4] | 0,01 [0,01;0,01] |
| HbA1C, % | 8,7 [7,4;11,3] | 8,2 [7,1;9,9] |
| IgG4 Ab, μg/ml | 685,5 [418,1;1301,4]. | 987,1 [536,2;2127,3] |
| ALF, U/ml | 1,6 [0,8;1,1] | 1,7 [1,2;1;9] |
Table 1. Patients characteristics
| Ab, U/ml | a (n=21) | b (n=15) |
|---|---|---|
| ZnT8A | 219,7 [79,1;326,3] | 67,3 [16,9;139,5] |
| IA-2A | 233,5 [194,2;366,2] | 39,9 [13,5;115,3] |
| GADA | 384,4 [13,2;1526,1] | 23,5 [5,2;27,0] |
Table 2. Pancreatic β-cell Ab positive titres
All of 78 patients with T1D were negative for ALF Aab. In group "a" all patients were negative for IgG4 and in group "b" 3 (6,5%) were positive (Aab levels – 4897,2; 3813,7; 3479,6). We didn't find association between IgG4, ALF levels and HbA1C, fasting c-peptide and b-cell Ab p<0,05. Patients in group "b" had higher IgG4 and ALF than in group "a", p<0,05.
Conclusions
The present data didn’t confirm the high presence of IgG4 and ALF in T1D, but higher Ab levels was found in long-standing T1D.
GASTROISTESTINAL IMMUNE DISORDERS IN PATIENTS WITH TYPE 1 DIABETES - ROLE OF VITAMIN D.
Abstract
Background and Aims
Vitamin D deficiency has been reported in several autoimmune conditions The role of autoimmune gastritis in the pathogenesis of nutritional deficiencies has been revealed, therefore we assumed a possible association between gastric parietal cells autoantibodies (PCA) and 25(OH)D deficiencyin T1D patients.The aim of this study was to evaluate the prevalence of 25(OH)D deficiency in patients with T1D and Vitamin D status association with PCA.
Methods
78 T1D patients (42 females; mean age 43.5 ± 12.8 years) were followed-up in Endocrinology research Centre from November 2018 to May 2019. 25(OH)D, parathormone, calcium, PCA measured in all T1D patients. We also evaluated autoantibodies to glutamic acid decarboxylase (GAD), islet antigen 2 (IA2) and zinc transporter isoform-8 (Znt8) to confirm the autoimmune genesis of diabetes.The results were compared with a control group of 42 healthy subjects.
Results
In T1D group (n=78) 25(OH)D levels were significantly lower than in the control group 14,6 [9,1;23,0] vs 27,0 [22,1; 34,7] ng/ml, p < 0,0001.
29 out of 78 patients with T1D were positive to PCA.Vitamin D values in these groups were 17,3 [9.9 23.6] and 12 ,4 [7,1;23,0] respectively.
Only 3 out of 42 patients (7%) were positive to PCA in control group without autoimmune diseases.
Conclusions
Data from the present study showed a significant reduction of 25(OH)D levels in T1D patients. No difference in Vitamin D status was found in patients with and without PCA. Possible impairment of vitamin D absorption in autoimmune gastritis may be caused by mucosal atrophy which may appear years after PCA start to be detectable in blood.