This prospective study examined whether baseline serum uric acid (SUA) levels predict all-cause or cardiovascular disease (CVD) mortality in Chinese elderly male adults with impaired glucose tolerance (IGT).
Between Apr 1st 2006 and Aug 31th 2015, 2676 elderly men underwent an oral glucose tolerance test (OGTT), SUA measurement and assessment of traditional CVD risk factors in health check up. Of these, 361 individuals were diagnosed as IGT. The cohort included 334 participants, who were followed for a mean period of 5.82 years. The independent association between SUA concentrations with all-cause or cardiovascular mortality or non CVD mortality was assessed by Cox proportional hazards models with or without adjustment for conventional risk factors and several potential confounders.
Baseline age was 66-100 years. During follow-up, 61 (18.26%) patients died, 19.67% (n=12) of whom were attributed to cardiovascular causes. However, the most frequent causes of death were cancer (n=21; 34.42% of total) and pneumonia (n=21, 34.42% of total). In univariate analysis, baseline SUA levels were not significantly associated with increased risk of all-cause or cardiovascular mortality. After adjustment for age, history of previous CVD, history of previous CVD events, smoking status, BMI, fasting blood glucose, systolic blood pressure, diastolic blood pressure, serum total cholesterol, serum triglycerides and glomerular filtration rate, SUA had limited influence on cardiovascular mortality or all-cause or non-cardiovascular mortality.
SUA levels were not associated with increased risk of cardiovascular mortality or all-cause mortality in Chinese elderly male patients with IGT, independent of several potential confounders.