NON-INVASIVE GLUCOSE MONITORING BY A RAMAN SPECTROSCOPY-BASED PROTOTYPE AFTER MEAL CHALLENGE IN TYPE 1 DIABETES
- Stefan Pleus, Germany
- Stefan Pleus, Germany
- Delia Waldenmaier, Germany
- Peter Wintergerst, Germany
- Nina Jendrike, Germany
- Manuela Link, Germany
- Cornelia Haug, Germany
- Guido Freckmann, Germany
Abstract
Background and Aims
One of the most promising technologies for non-invasive glucose monitoring (NIGM) in diabetes is Raman spectroscopy. We assessed the performance of a novel prototype in comparison with standard capillary blood glucose monitoring (BGM) and intermittent scanning continuous glucose monitoring (iscCGM).
Methods
In total, 15 subjects with type 1 diabetes underwent a carbohydrate-rich meal challenge during which BGM, iscCGM and NIGM measurements were performed for 450 min.
Results
Mean glucose values for the 3 monitoring systems are shown in the figure exhibiting a good match. The closeness of agreement generally improved with lower rates of change. During the initial 60 min after the standardized meal, the rates of change were: BGM, 2.0 ± 1.7 mg/dl/min, iscCGM, 1.5 ± 1.2 mg/dl/min, and NIGM, 0.8 ± 1.5 mg/dl/min (mean ± standard deviation).
Conclusions
In this proof-of-concept study, average glucose readings using NIGM showed good agreement with mean BGM and iscCGM data. The agreement improved with lower rates of change, indicating an effect of varying signal delay between the methods.