The aim of the present study was to examine vitamin D status and its relation with bone metabolism in adult patients with T1DM.
We studied 118 patients with T1DM (Group-D) (mean age:35.4+10.3years) and 94 healthy controls (Group-C) matched for age, sex and BMI. In both groups HbA1c, 25(OH)Vitamin D (Vit-D), Ca, Ph, Mg, ALP, albumin, PTH, β-crosslaps, type 1 procollagen total N-terminal propeptide (TP1NP) were measured. Vit-D levels 30-50ng/ml were defined as optimal concentration(OC), 20-30ng/ml as suboptimal concentration(SC), 10-20ng/ml as deficiency(DE) and 0-10ng/ml as insufficiency(IN).
In Group-D, mean duration of DM was 16.2+9.5years and mean HbA1c was 7.8+1.4%. In Group-D, Vit-D OC occurred in 20%, SC occurred in 27.1%, DE occurred in 34.3%, with the remaining 18.6% having a Vit-D level below 10 ng/m (IN). In Group-C, Vit-D OC occurred in 23.4%, SC occurred in 31.6%, DE occurred in 28.4%, with the remaining 16.6% having a Vit-D level below 10 ng/mL (IN). The overall mean Vit-D levels were not significantly different between groups (D:20.4+11.0vsC:21.2+8.4, p=0.743). Also, Ca, Ph, Mg, ALP and PTH levels were comparable in both groups. B-crosslaps were significant lower in Group-D compared to control (D:325.7+198.9vsC:442.8+220.6, p=0.002) but TP1NP were lower in Group-D but not statistical significant (D:50.34+30.97vsC:53.12+24.43, p=0.594). In T1DM patients, no correlation was found between Vit-D and HbA1c (r=0.032,p=0.794), Vit-D and β-crosslaps (r=-0.004,p=0.976) and Vit-D and TP1NP (r=0.009,p=0.944).
These data suggest that Vit-D and calcium metabolism in patients with T1DM were comparable with the controls and were not correlated with glycemic control and bone metabolism.