ADRB2 is the gene that encodes beta-2 adrenergic receptors which play the key role in the mobilization of lipids.
The aim of work is to study the changes in body composition depending on the rs1042713 ADRB2 gene in overweight patients treated by the diet.
18 overweight patients (from 23 to 60 y.o., the mean age 45,39±12,71; the mean BMI 33,71±5,48 kg/m2) were evaluated. All patients took a diet with limiting of simplex and complex carbohydrates and fats for 3 months. Body composition was evaluated by bioelectrical impedance analysis (BIA). PCR-based genotyping was performed on CFX96 analisator; buccal cells were used.
The distribution of the frequency of alleles and genotypes corresponded to the Hardy-Weinberg equilibrium (χ2=0,000172531; p>0,05). A significant decrease of fat mass in patients with the absence of G-allele (-5,67±2,55 kg) relative to the group of carriers of the mutant allele (-2,73±2,759 kg; p=0,05) was revealed. All patients were invited for BIA 9 months after. Although there were no significant differences in changes of fat mass between the groups, G-allele carriers had less weight gain than the patients with the absence of the mutant allele. (0,22±2,24 kg vs. 2,44±2,02 kg; p=0,04).
Identification of the allele G of rs1042713 ADRB2 gene allows predicting a less intense loss of body fat mass during the common diet therapy of obesity and prognosing worse weight control in future.