The international consensus regarding clinical targets for CGM recommended that the majority of PWT1D should reach a TIR (70-180 mg/dL) of >70% of the total time. However, it is unclear how often these targets are achieved and what factors are associated with the achievement of TIR targets. The aim of this prospective observational study was to assess the feasibility and associated factors of reaching recommended TIR targets.
PWT1D using a flash glucose monitoring (FlashGM) system for 3 months with >80% of sensor data available were included. Diabetes self-management with MDI was performed during this 3-month period. FlashGM data were downloaded and assessed for the percentage of PWT1D achieving the recommended glycaemic targets. A forward stepwise linear regression was performed to model variables explaining achievement of TIR targets (p≤0.05).
81 PWT1D (40 females, age 43±15 years, BMI 25±3 kg/m2, HbA1c 57±9 mmol/mol, diabetes duration 18±13 years, pre-investigation FlashGM use 302±225 days) were included. The following number/percentage of PWT1D reached the recommendations:
| N=81 | Recommendation | Recommendation achieved |
| TBR-level 2 | <1% <54mg/dL | N=23; 28% |
| TBR-level 1 | <4% <70mg/dL | N=33; 41% |
| TIR | >70% 70-180mg/dL | N=13; 16% |
| TAR-level 1 | <25% >180mg/dL | N=20; 25% |
| TAR-level 2 | <5% >250mg/dL | N=16; 20% |
TIR was associated with the number of scans per day (β=0.50, p<0.001), c-peptide status (β=0.32, p=0.004) and BMI (β=-0.29, p=0.007).
Only few PWT1D achieve recommended glucose targets. However, those who performed more scans accompanied with a higher c-peptide level as well as a lower BMI more often achieved the recommended glycaemic targets.