NASAL VERSUS INJECTED GLUCAGON: USER EXPERIENCE RESULTS OF A SIMULATED SEVERE HYPOGLYCEMIA STUDY
- Christopher J. Child, United States of America
- Christopher J. Child, United States of America
- Gregg Gerety, United States of America
- Sanjay Bajpai, United States of America
- Erik Spaepen, United States of America
- Jeffrey G. Suico, United States of America
- Julie Settles, United States of America
Abstract
Background and Aims
Use of injectable glucagon (IG) challenges caregivers of a person with diabetes (PWD) during stressful severe hypoglycemia (SH) rescue. Success rates, administration time, and user preference for nasal glucagon (NG) vs IG devices were evaluated after treating SH simulations.
Methods
Adult PWDs were trained to use NG or IG, and then trained their caregivers (1 hour later) in its use; 1 week later, caregivers attempted administration to a manikin exhibiting SH in a simulated real life setting. Untrained adults were shown the device pre-simulation. After 1 week, procedures were repeated with the alternative device. Proportions of success with each device (complete dose+critical steps) and administration times were studied. Device comparative questionnaires were completed after viewing videos of simulations after the second simulation.
Results
Of PWD trained users, 90% and 16% were successful with NG and IG, respectively (McNemar p<0.0001). Similarly, 91% of untrained users were successful with NG, 0% with IG (p<0.0001). Median time to NG success was 30 sec (trained and untrained users); 5 trained users successful with IG took 73 sec. NG was rated preferred by those successful with NG or IG, and PWDs indicated feeling safer with NG even with IG success (Table).
Conclusions
PWD-trained and untrained users were more successful and faster in administering NG than IG. None of the few preferring IG were successful with IG, while the few successful IG-users preferred NG or stated no preference. Training was not critical for NG success and ease of preparation/use likely contribute to overall preference.
