Type 1 diabetes mellitus is a chronic condition with a high degree of self-management burden that can significantly negatively impact quality of life. Advances in diabetes technology have led to improvements in overall metabolic control but have been less successful at decreasing user and caregiver burden. Advanced diabetes devices and integrated automated systems hold the promise to finally simultaneously improve glycemic control and quality of life. Successful adoption of these devices, however, requires not only that they can improve glycemic control, but that they can also be introduced and incorporated into daily living. Such human factors issues as comfort, wearability, trust, and ease of use are as important as accuracy and precision. In this presentation we will discuss how human factors issues have shaped the evolution of advanced diabetes devices and highlight features important to potential users of these devices.