The expression of human epidermal growth factor receptors 2 (HER2) and hormonal receptors (estrogen receptor and progesterone receptors) on breast cancer are important markers that always be determined on breast cancer patients. Association between HER2 and hormonal receptors (ER and PR) expression are used as a prognostic and predictive factor on breast cancer. This research aimed to determine the association between HER2, ER, and PR on breast cancer.
This study was an analytical with cross-sectional design. This study was conducted from May 2015 – December 2015 in oncology division of surgery department RSUP DR. M. Djamil, Padang. Research subjects were 373 of breast cancer patients from 2011 – 2015. Chi square analysis test was used to determine the significant relationship between the variables.
This study involved 124 cases with HER2+ and 249 cases with HER2-. Significant differences in the cases were ER+/HER2- (85.2%) compared with ER+/HER2 (14.8%) with p < 0.001. We also obtained the same tendency on PR+/HER2- (82.7%) compared with PR+/HER2 + (17.3%) with p < 0.001.
This study concluded that there were significant differences between expression of HER2 and hormonal receptors (ER and PR).
This is not a trial idetification research
Medical Faculty of Andalas University
None
All authors have declared no conflicts of interest.