Luxembourg Institute of Health
Department of Precision Health
Dr Aguayo has an MD from the Catholic University of Chile, an MSc in clinical epidemiology from the Erasmus University Rotterdam and a PhD in public health from the University of Liège. She currently works in the deep digital phenotyping research unit at the Department of Precision Health at the Luxembourg Institute of Health. She also participates in the National Centre for Excellence in Research on Parkinson's Disease (NCER-PD) as an epidemiologist. Her main interests are the epidemiology of Parkinson's and its risk factors, healthy ageing, frailty trajectories, diabetes, digital health and sleep patterns. She is interested in methodology techniques such as multiple imputations, longitudinal trajectory analysis, survival analysis, clustering and deep learning. She has participated in designing clinical trials and observational studies in the general population, adding objective measures of sleep and physical functioning and studying the impact of quantity and quality of sleep on disease and disease risk.

Presenter of 2 Presentations

THE LUXEMBOURG SLEEP STUDY: REM SLEEP BEHAVIOR DISORDER EPIDEMIOLOGICAL ANALYSIS

Session Type
SYMPOSIUM
Date
Sat, 01.04.2023
Session Time
14:45 - 16:45
Room
ONSITE - HALL G2
Lecture Time
15:45 - 16:00

Abstract

Aims

Idiopathic REM Sleep Behaviour Disorder (iRBD) is the most robust prodromal sign of α-synucleinopathies (α-Syn) where Parkinson’s disease (PD) is the most common. Up to 90% of iRBD converts eventually to α-Syn after 15 years of follow-up. We aim to assess the prevalence of people with RBD symptoms and to build a prodromal cohort of iRBD.

Methods

Between February and June 2021, all residents of Luxembourg aged 55-75 were invited to participate in an online survey including the one-item Mayo Sleep Questionnaire, RBD Screening Questionnaire (RBDSQ), and Short IQCODE, indicative of probable RBD (pRBD) or cognitive decline. We applied a threshold of RBDSQ ≥7 for suggesting the presence of pRBD and multiple imputations for dealing with missing data. We fitted multiple regression models for identifying predictors of pRBD symptoms.

Results

Invitations were sent to 134,098 Luxembourg residents with response rate of 13% (n=17,502). We included 15,921 participants with complete sleep data: 54% were men, and the median age was 62 (58-67). We found that 12.6% of the total corresponded to probable RBD (12.3% of women and 12.9% of men). Age, the language of participation, and cognitive decline were significant predictors of pRBD.

Conclusions

This study is one of the most extensive nationwide population-based screening studies focused on RBD. In contrast to the literature(1), our results showed a higher prevalence of RBD, probably due to different cutoffs, populations/screening instruments, and at-risk people responding with higher motivation. A validation concept is currently ongoing using telephone interviews, face-to-face assessment, and polysomnography.

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THE LUXEMBOURG SLEEP STUDY: REM SLEEP BEHAVIOR DISORDER EPIDEMIOLOGICAL ANALYSIS

Session Name
0570 - ONSITE SYMPOSIUM: EEG, SLEEP AND OTHER ASSESSMENT TOOLS (ID 465)
Session Type
G2+G4_POSTERS & ON-DEMAND GALLERY
Date
Sat, 01.04.2023
Session Time
14:45 - 16:45
Room
ON-DEMAND VIRTUAL GALLERY
Lecture Time
15:45 - 16:00