Presenter of 2 Presentations
THE LUXEMBOURG SLEEP STUDY: REM SLEEP BEHAVIOR DISORDER EPIDEMIOLOGICAL ANALYSIS
Abstract
Aims
Idiopathic REM Sleep Behaviour Disorder (iRBD) is the most robust prodromal sign of α-synucleinopathies (α-Syn) where Parkinson’s disease (PD) is the most common. Up to 90% of iRBD converts eventually to α-Syn after 15 years of follow-up. We aim to assess the prevalence of people with RBD symptoms and to build a prodromal cohort of iRBD.
Methods
Between February and June 2021, all residents of Luxembourg aged 55-75 were invited to participate in an online survey including the one-item Mayo Sleep Questionnaire, RBD Screening Questionnaire (RBDSQ), and Short IQCODE, indicative of probable RBD (pRBD) or cognitive decline. We applied a threshold of RBDSQ ≥7 for suggesting the presence of pRBD and multiple imputations for dealing with missing data. We fitted multiple regression models for identifying predictors of pRBD symptoms.
Results
Invitations were sent to 134,098 Luxembourg residents with response rate of 13% (n=17,502). We included 15,921 participants with complete sleep data: 54% were men, and the median age was 62 (58-67). We found that 12.6% of the total corresponded to probable RBD (12.3% of women and 12.9% of men). Age, the language of participation, and cognitive decline were significant predictors of pRBD.
Conclusions
This study is one of the most extensive nationwide population-based screening studies focused on RBD. In contrast to the literature(1), our results showed a higher prevalence of RBD, probably due to different cutoffs, populations/screening instruments, and at-risk people responding with higher motivation. A validation concept is currently ongoing using telephone interviews, face-to-face assessment, and polysomnography.