Amsterdam UMC, Vrije Universiteit Amsterdam
Department of Anatomy and Neurosciences
Wilma van de Berg is senior neuroscientist, principal investigator, associate professsor at dept. Anatomy and Neurosciences, head of the research section Clinical Neuroanatomy and Biobanking (CNAB). She is founder and director of the Normal Aging Brain Collection (www.nabca.eu), which collects advanced postmortem MRI and high-quality brain tissue of non-demented elderly for stimulating translational research in neurosciences. Wilma van de Berg is an expert in human neuroanatomy, neuropathology and morphometry of Parkinson's disease. She has a strong interest in translating knowledge on pathogenesis in Parkinson's diseasse in novel (progression) biomarkers and developing new disease-modifying treatment strategies aiming to slow down or halt Parkinson’s disease progression. Her research team studies human brain morphology, neuropathological lesions and molecular mechanisms underlying alpha-synuclein aggregation in postmortem brain tissue of aged individuals and patients with Parkinson’s disease, Dementia with Lewy bodies and Alzheimer’s disease from macro-to-nanoscale using advanced MRI, correlative microscopic imaging and multi-omics methods. Wilma van de Berg has experience in conducting clinical studies (e.g. PROGRES-PD) in which Parkinson patients were followed for eight years to study relationship between biofluid markers and cognitive decline in PD. In close collaboration with acadmic and industry partners, she setup a large multicenter longitudinal observational study ‘Profiling Parkinson’s disease’ (ProPARK) to identify molecular profiles underlying disease severity, progression and adverse drug reactions and translate this knowledge into biomarker panels for next clinical trials.

Moderator of 1 Session

Session Type
SYMPOSIUM
Date
Fri, 18.03.2022
Session Time
05:15 PM - 07:15 PM
Room
ONSITE: 133-134

Presenter of 1 Presentation

PROFILING PARKINSON’S DISEASE (PROPARK): AN OBSERVATIONAL, MULTICENTER, LONGITUDINAL COHORT STUDY DESIGNED TO IDENTIFY A PARKCODE FOR PARKINSON’S

Session Type
SYMPOSIUM
Date
Fri, 18.03.2022
Session Time
05:15 PM - 07:15 PM
Room
ONSITE: 133-134
Lecture Time
05:15 PM - 05:30 PM

Abstract

Aims

To personalize current and future medical treatment in Parkinson’s disease (PD) there is an urgent need for identification of molecular profiles underlying between-patient differences in phenotype expression, treatment response and susceptibility to adverse drug reactions (ADRs). Here, we present the observational cohort study, named ‘Profiling Parkinson’s disease’ (ProPark), which is designed to identify a ‘ParkCode’ reflecting molecular profiles in PD.

Methods

ProPark is a longitudinal, multicenter cohort study in which 1250 PD patients with a disease duration of <10 years, as well as 265 age- and gender-matched controls will be recruited by a collaborative network in the Netherlands. We will collect phenotypic data, including neurological, neuropsychological and psychiatric assessments at baseline and follow-up (3 years). In addition, we will collect extensive wearable-sensor-derived kinematic data and blood (DNA, serum, plasma and PBMCs) and stool annually, and from a subset of patients also skin biopsies, CSF and brain-MRI.

Results

We will develop a biobank containing comprehensive and uniformly acquired longitudinal clinical data and biological samples for identification and validation of existing and novel (quantitative) biomarkers reflecting the Parkinson’s phenotype. In addition, we will develop data-driven approaches to unravel heterogeneity in the Parkinson’s phenotype. Main study parameters are biomarker concentrations (i.e. blood & stoo microbiome), skin alpha-synuclein aggregation, treatment response, ADR occurrence and cognitive and neuropsychiatric scores.

Conclusions

ProPark will integrate longitudinal clinical and biomarker data into a ‘ParkCode’ which may guide towards a more tailored use of current available symptomatic treatment and the development of disease-modifying therapies.

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