Butler Hospital
Neurology, Memory and Aging Program
Dr. Salloway received his MD from Stanford Medical School and completed residencies in neurology and psychiatry at Yale University. He is the Martin M. Zucker Professor of Psychiatry and Human Behavior, and Professor of Neurology at the Warren Alpert Medical School of Brown University, and Chief of Neurology and Director of the Memory and Aging Program at Butler Hospital. Dr. Salloway is an internationally recognized leader in clinical trials for the prevention and treatment of Alzheimer’s disease. His program has conducted more than 100 clinical trials for Alzheimer’s and related disorders. He has chaired the Steering Committees for major AD pivotal trials and he has been a lead author for key publications in Alzheimer’s research in the New England Journal of Medicine, Nature and other top-tiered journals that have helped shaped the field of Alzheimer’s research. He also serves on the steering committees for major biomarker and clinical trials and consortia such as ADNI, DIAN, ACTC, GAP-NET and LEADS and he is a Project Arm Leader for the DIAN-TU study. Dr. Salloway has had a distinguished teaching career mentoring young investigators for careers in Alzheimer’s research. He has received numerous teaching awards at Brown and he helped establish Brown’s combined residency in neurology and psychiatry and the NIH-funded Dementia Research Fellowship. He is the Past President of the American Neuropsychiatric Association, a Fellow of the American Academy of Neurology and a member of the American Neurological Association. He serves as a consultant for drug development to the NIH, the Alzheimer’s Association, the Alzheimer’s Disease Drug Discovery Foundation and many other groups working on Alzheimer’s therapeutics. He has published more than 400 scientific articles and abstracts and edited 3 books and he lectures widely about the early diagnosis and prevention of Alzheimer’s disease. In May 2019 he was elected to the Rhode Island Heritage Hall of Fame for his work on Alzheimer’s research.

Presenter of 1 Presentation

PRE-RECORDED: New and Emerging Treatments for Alzheimer's Disease

Session Type
SYMPOSIUM
Date
Sat, 19.03.2022
Session Time
09:10 AM - 11:10 AM
Room
ONSITE: 112
Lecture Time
10:25 AM - 10:40 AM

Abstract

Abstract Body

Alzheimer’s disease represents an epidemic within a pandemic in our aging world. The disease currently has no meaningful treatment to slow progression but we are on the verge of breakthroughs in Alzheimer’s disease research thanks to the inspiring contributions of thousands of study participants and the dedication of talented researchers. This presentation will review the progress we have made and the challenges we face to create pathways for major advances in diagnosis and treatment.

In 2012 the United States launched the National Plan to Address Against Alzheimer’s Disease which has led to a dramatic increase in AD research funding from the National Institutes of Health. The NIH has partnered with industry and foundation funders to create landmark observational trials that have advanced our understanding of the evolution of AD pathogenesis. Advances in molecular brain imaging can now safely detect AD pathological changes years before cognitive decline, opening the era for Alzheimer’s prevention. Drugs that modify amyloid and tau to slow the disease course are currently under regulatory review. Promising plasma and digital biomarkers will soon be available to make early diagnosis and screening for trials and treatment more widely available and cost-effective. Encouraging gene-modifying strategies that have shown important benefits in other neurological diseases are now being tested for AD and other neurodegenerative disorders.

Many important challenges lay ahead that include expanding public-private partnerships to meet our research goals and prioritizing the training of talented young investigators to develop the necessary research work force, We will need to implement practical screening tests and access to emerging treatments on a global scale and multi-targeted discovery science and lifestyle interventions to pioneer combination treatments.

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