Moderator of 1 Session
Presenter of 1 Presentation
REPEATED INFUSION OF AUTOLOGOUS ADIPOSE TISSUE-DERIVED STEM CELLS FOR MULTIPLE SYSTEM ATROPHY
Abstract
Aims
Autologous adipose tissue-derived stem cells (ADSCs) have been shown to have the ability to repair nerve cells and myelin sheaths, have anti-inflammatory effects, and improve blood flow, as well as the potential to degrade and remove insoluble proteins. We have confirmed the safety of repeated intravenous administration of ADSCs for Alzheimer's disease, Parkinson's disease, and ALS, and have experienced multiple cases of symptomatic improvements. We hypothesize that ADSCs treatment is effective for neurodegenerative diseases including MSA.
Methods
ADSCs were administered intravenously to eight patients with multiple system atrophy (MSA; MSA consisted of one MSA-p and seven MSA-c) six times approximately every month. Patients were evaluated by neurological findings, modified Rankin Scale (mRS), ALSFRS-R (ALS Functional Rating Scale), and interviews with themselves and their caregivers.
Results
No adverse reactions were observed. There was no deterioration in vital signs, no significant worsening of blood chemistry, and no evidence of Amyloid Related Imaging Abnormalities (ARIA) on MRI. The mRS and ALSFRS scores were maintained during the observation period, and three patients showed improvement in subjective symptoms, including less swelling, ability to handle a pen, and opening the cap of a plastic bottle.
Conclusions
Intravenous administration of ADSCs appears to be promising for MSA, as well as for neurodegenerative diseases such as Alzheimer's, Parkinson's, and ALS. In neurodegenerative diseases, abnormal protein deposits occur in the brain, which correlates with aging, and ADSCs may have a mechanism to prevent these deposits.