Dr. Pasinetti is the Saunders Family Chair and Professor of Neurology, and Chief of the Neurodiagnostics and Neurotherapeutics division of the Friedman Brain Institute at The Icahn School of Medicine at Mount Sinai. He is also the Director of Basic and Biomedical Research and Training Program at GRECC of the James J. Peters Veterans Affairs Medical Center, Bronx, NY. He has a strong record of successful and productive research endeavors exploring the mechanisms associated with mood disorders and neurodegenerative conditions. Over the past 30 years, his research has focused on developing model systems of brain disorders in order to better understand and clarify their underlying mechanisms. His previous experience as director of the Center of Excellence for Research on CAM (P01) focused on how polyphenol metabolites interact with multiple neuropathological features in Alzheimer’s disease, such as synaptic maladaptation, Aβ neurotoxicity, and disruption of neuronal microtubule-associated tau proteins leading to impaired axonal transport. In the past few years, his research has been tailored to understanding how psychological stress and environmental toxins may both generate depressive phenotypes as well as lead to anatomical and molecular changes in the brain. Some of these changes are now implicated as potential risk factors for developing neurodegenerative disorders. Toward developing preventative and therapeutic approaches for neurological disorders, he investigated how dietary polyphenols possess anti-inflammatory characteristics in vivo, and how they may promote resilience against the development of mood disorders, with an emphasis on depression and anxiety.