CEITEC MU
Applied neuroscience
Irena Rektorova, MD, Ph.D. is Professor of Neurology and Scientific Director of the International Clinical Research Centre at St. Anne’s University Hospital in Brno, Czech Republic. She is also Head of the Movement Disorders Centre at the First Department of Neurology, School of Medicine and of the Applied Neuroscience Research Group at Central European Institute of Technology (CEITEC), Masaryk University in Brno, Czech Republic.
Moderator of 1 Session
SYMPOSIUM
Session Type
SYMPOSIUM
Date
Thu, 17.03.2022
Session Time
05:15 PM - 06:45 PM
Room
ONSITE: 131-132
Presenter of 1 Presentation
EEG AS A MARKER OF PSYCHIATRIC AND COGNITIVE SYMPTOMS IN PRODROMAL DEMENTIA WITH LEWY BODIES
Session Type
SYMPOSIUM
Date
Thu, 17.03.2022
Session Time
05:15 PM - 06:45 PM
Room
ONSITE: 131-132
Lecture Time
06:00 PM - 06:15 PM
Presenter
Abstract
Abstract Body
Background: Electrophysiological markers of prodromal dementia with Lewy bodieswere described in the spectral domain. The sub-second temporal resolution may provide additional information.
Objective: 1. To evaluate electroencephalography (EEG) microstates in patients with mild cognitive impairment with Lewy bodies (MCI-LB) and to assess the association between their temporal dynamics and the spectral marker, 2. To assess EEG microstate changes with the disease progression at 1year follow-up visit and the association with psychiatric and cognitive symptoms.
Methods: Temporal parameters of EEG microstates were compared between 21 patients with MCI-LB and 21 healthy controls. The dominant alpha frequency was correlated with microstate parameters. Changes in EEG microstates were assessed in the MCI-LB at 1-year follow-up visit and correlated with depressive symptoms and cognitive outcomes.
Results: Microstates A-D showed higher occurrence in the patient group. Microstate B which is attributed to the visual network revealed shorter mean duration and increased time coverage; its occurrence correlated with the dominant alpha frequency in the patient group. At one-year follow-up, MCI-LB subjects demonstrated higher time coverage, occurrence and duration of microstate D (which is attributed to the he frontoparietal network) as compared to the baseline visit. The changes in microstate D parameters were related to psychiatric symptoms changes and cognitive decline in the MCI-LB group.
Conclusions: Temporal dynamics of all EEG microstates were altered in medication-naïve subjects with prodromal dementia with Lewy bodies. Longitudinal
follow-up revealed changes in the microstate engaged in attention and executive function that correlated with both cognitive and affective symptoms of MCI-LB.
The study was supported by the AZV grant of the Czech Ministry of Health NU20-04-00294 and European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 734718 (CoBeN).