Daniel Ferreira (Sweden)
Karolinska Institutet
Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society
Dr. Daniel Ferreira is a Principal Investigator at Karolinska Institutet (Sweden) and Research Affiliate at Mayo Clinic (US). He is Director of the Center for Alzheimer Research at KI (https://ki.se/en/nvs/center-for-alzheimer-research). Main research interest of Dr. Ferreira is Normal Aging and neurodegenerative disorders such as Dementia with Lewy bodies and Alzheimer’s disease. His main focus is on cognition and neuroimaging but genetic factors, CSF biomarkers, and clinical and demographic factors are part of his research as well. More information: https://staff.ki.se/people/daniel-ferreira-padilla twitter: @DrFerreiraD

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AMYLOID-BETA, TAU AND CEREBROVASCULAR PATHOLOGIES ASSOCIATE WITH NEURODEGENERATION DIFFERENTLY IN ALZHEIMER’S DISEASE, DEMENTIA WITH LEWY BODIES AND NORMAL AGING

Session Name
0840 - CONGOPHILIC AMYLOID ANGIOPATHY (CAA), VASCULAR DEMENTIA, VASCULAR DAMAGE IN DEMENTIA, BLOOD-BRAIN BARRIER, ARIA (ID 48)
Session Type
SYMPOSIUM
Date
Thu, 17.03.2022
Session Time
05:15 PM - 07:15 PM
Room
ONSITE: 112
Lecture Time
06:30 PM - 06:45 PM
Presenter

Abstract

Aims

Associations of AD and cerebrovascular pathologies with neurodegeneration in aging and dementia is not fully understood. We investigated biomarkers of amyloid-beta, tau neurofibrillary tangle (NFT), and cerebrovascular pathology in relation to regional GM volume in patients with dementia with Lewy bodies (DLB), in comparison to Alzheimer’s disease (AD) and cognitively unimpaired (CU) elderly.

Methods

We included 30 DLB and 48 AD dementia patients from the Mayo Clinic ADRC, who underwent 11C-PiB PET, 18F-Flortaucipir PET, and MRI. An age and sex matched CU group was also included (n=100). We conducted univariate and multivariable analyses to investigate unique and combined associations of PiB standard uptake value ratio (SUVr), Flortaucipir SUVr and WMH volume with regional GM volume as a marker of neurodegeneration.

Results

In DLB, higher Flortaucipir SUVr was associated with GM atrophy in the fusiform cortex and WMH volume predicted neurodegeneration in inferior-medial frontal lobe and insula in the multivariable model. In contrast, in AD dementia, Flortaucipir SUVr was associated with GM atrophy involving most of the cortex. In CU, elevation in all three biomarkers (PiB and Flortaucipir SUVrs, and WMH volume) were associated with neurodegeneration in the medial temporal lobe and WMH was associated with atrophy in the insula and orbitofrontal regions.

Conclusions

Although amyloid-beta, tau NFT, and cerebrovascular pathologies often coexist in DLB, AD dementia, and CU, their associations with neurodegeneration seem to be different, which may in part determine pathogenesis and clinical expression.

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