P015 - ASSOCIATION OF AMYLOID Β AND DNA REPAIR ACTIVITY OF MIDDLE-AGED WOMEN PARTICIPATED IN BEACH FITNESS RETREAT PROGRAM (ID 823)
Abstract
Aims
Amyloid β (Aβ) can cause DNA damage by inducing ROS, and Alzheimer's disease (AD) patients are known to have a defective ability to DNA repair. However, there have been a few studies on the associations between Aβ levels and DNA repair capacities. Therefore, the purpose of this study was to investigate the effects of short-term beach fitness retreat program (BFRP) on DNA repair activity and Aβ level in middle-aged women.
Methods
Total of forty middle-aged women from age 50-64 were recruited after confirming normal cognitive function by MMSE. And the BFRP is composed of two hours of Nordic walking and another two hours of beach yoga every day during the 5 days of program in Wando, Korea.
Results
DNA repair activity (DRA) increased in twenty subjects and decreased in seventeen subjects. The DRA increase group showed a significant increase of DNA repair activity comparing before and after BFRP (p<.003) with decrease of Aβ levels from 0.6965±0,04 to 0.6624±0.05 (Table 1). The Pearson correlation coefficient between the change of DRA and Aβ levels in this group was 0.402 (p=0.098) in Fig 1. However, the DRA decrease group showed a significant decrease of DNA repair activity comparing before and after BFRP (p<.007) and showed increase of Aβ levels from 0.6413±0.08 to 0.7266±0.02 with insignificant correlation (r=-0.145, p=0.621).
Conclusions
The short-term BFRP had a possible positive effect to reduce Aβ in DRA increase group in middle-aged women and it is needed to evaluate the association between Aβ levels and DRA in larger study subjects.
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