P018 - BNIP3 SELECTIVELY EXPRESSES IN ENTORHINAL CORTEX LAYER II-NEURONS THAT ALSO EXPRESS REELIN (ID 1556)
Abstract
Aims
Characterization of Bnip3 expression in rodent and human brain.
Methods
Immunohistochemistry, western blotting
Results
In a rat model for AD (McGill-R-Thy1-APP model) expressing human mutated APP, experiments revealed that in EC, Reelin-expressing layer II neurons selectively stain positive for intracellular Aβ at the pre-plaque stage, and this might hold true also for early-stage AD subjects (Kobro-Flatmoen et al., 2016). Here we show that this population also selectively expresses Bcl-2/adenovirus E1B 19KDa-interacting protein (Bnip3).
Conclusions
The selective expression of Bnip3 in EC layer II-neurons is of interest since Bnip3 participates in mitophagy but can under certain conditions cause caspase-independent neuronal death.
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