P031 - ROLE OF MONOCYTES IN THE DEVELOPMENT OF ALZHEIMER'S DISEASE (ID 1702)
Abstract
Aims
To determine whether the activation of monocytes can be used as a biomarker for the progression of Alzheimer's disease (AD).
Methods
We separated form healthy, mild cognitive impairement (MCI) and Ad patients their monocytes. We derermined by FACScan the phenotypes of these monocytes, their functionality and their capacity to differentiate in macrophages.
Results
We found that monocytes were already activated at the MCI stage mainly regarding the free radical production. In the mean time there was a shift in the phenotypes of moncytes toward the non-classical subsets. The differentiation was also shifted to M2 phenotype.
Conclusions
We conclude that monocytes as they are activated already as in the MCI stage of the disease may serve as biomarkers and could represent a good target for treatement options.
