OO017 - THE EFFECT OF A MINDFULNESS-BASED VERSUS HEALTH SELF-MANAGEMENT INTERVENTION ON COGNITIVE PERFORMANCE IN OLDER ADULTS WITH SUBJECTIVE COGNITIVE DECLINE (SCD): THE SCD-WELL RANDOMIZED CONTROLLED TRIAL (ID 1476)
- Tim Whitfield (United Kingdom)
- Harriet Demnitz-King (United Kingdom)
- Marco Schlosser (United Kingdom)
- Thorsten Barnhofer (United Kingdom)
- Eric Frison (France)
- Nina Coll-Padros (Spain)
- Sophie Dautricourt (France)
- Florence Requier (Belgium)
- Marion Delarue (France)
- Julie Gonneaud (France)
- Olga M. Klimecki (Switzerland)
- Antoine Lutz (France)
- Léo Paly (France)
- Eric Salmon (Belgium)
- Ann-Katrin Schild (Germany)
- Zuzana Walker (United Kingdom)
- Frank Jessen (Germany)
- Gael Chetelat (France)
- Fabienne Collette (Belgium)
- Miranka Wirth (Germany)
- Natalie L. Marchant (United Kingdom)
Abstract
Aims
To test the hypothesis that a Caring Mindfulness-Based Approach for Seniors (CMBAS) intervention will confer greater benefit to objective cognition than a Health Self-Management Program (HSMP) in individuals with subjective cognitive decline (SCD).
Methods
This study utilized data from the SCD-Well RCT. Older adults with SCD (n=147) were recruited from memory clinics in four European countries, and randomized to an 8-week non-pharmacological intervention (either CMBAS or HSMP). Objective cognition was assessed at baseline, 8-weeks, and 24-weeks using a battery of tests. Three cognitive composites were also computed - an attention composite, executive composite, and abridged Preclinical Alzheimer’s Cognitive Composite 5 (PACC5Abridged). Linear mixed models estimated the change for each outcome within and between trial arms. All models were adjusted for demographics, baseline Alzheimer’s disease (AD) blood biomarkers (P-tau-181, NfL, and Abeta42/40), and neuropsychological retest effects.
Results
PACC5Abridged scores increased from week 0-24 in both arms of the trial (p<.001; see figure). The mean increase [95%CI] did not differ between arms (CMBAS=0.32, [0.17, 0.47]; HSMP=0.30, [0.15, 0.45]). Neither the attention nor the executive composite scores increased in either arm. Amongst individual cognitive tests, non-differing improvements were observed in both arms for the DRS-2, RAVLT, and WAIS-IV Coding. Neither trial arm exhibited improvement for verbal fluency, Stroop nor TMT.
Conclusions
Scores on a composite sensitive to early AD-related cognitive dysfunction improved in both arms, even after accounting for retest effects. This work adds to the growing body of evidence that non-pharmacological interventions can improve cognition in individuals with SCD, a population at increased dementia risk.
