Maria Teresa Ferretti, Switzerland

Women's Brain Project Chief Scientific Officer
Maria Teresa is a neuroimmunologist and science advocate with over 10-year international experience in the field of Alzheimer’s disease, and a unique expertise on sex and gender differences. After a master in Pharmaceutical Chemistry in 2005 (University of Cagliari, Italy) and a stage at the Center of Excellence for Drug Discovery of GlaxoSmith&Kline (Harlow, England), she obtained a PhD in Pharmacology and Therapeutics at McGill University (Montreal, Canada) in 2011 with a thesis on the role of inflammation in Alzheimer’s Disease. In 2011 she moved back to Europe and joined the Nitsch’s lab (University of Zurich, Switzerland) as postdoc and group leader, to identify novel biomarkers for increasing individual level prediction of cognitive decline and Alzheimer’s. In 2016 Maria Teresa co-founded the non-profit organization called ‘Women’s Brain Project’ (WBP, CHE-369.271.906), focusing on sex- and gender-sensitive precision medicine for brain and mental diseases such as Alzheimer, migraine, multiple sclerosis, depression etc (www.womensbrainproject.com). Her work as WBP Chief Scientific Officer has led to several scientific publications in leading journals including Nature, Science and PNAS, three TED-x talks (https://youtu.be/9nWpkv0o55U), and coverage by both the national (Sonntagszeitung, SwissInfo, NZZ, Le Temps) and the international press (including BBC, The Independent, Sciences et Avenir, Financial Times, La Stampa, ELLE Italy). She is currently Faculty member of the course in advanced studies for sex and gender differences offered by University of Zurich, and POL instructor at the Medical University of Vienna.

Moderator of 1 Session

LIVE SYMPOSIUM DISCUSSION

LIVE DISCUSSION - SEX AND GENDER IN NEURODEGENERATIVE DISEASES

Date
14.03.2021, Sunday
Session Time
15:30 - 16:00
Session Icon
Live

Presenter of 2 Presentations

SEX AND GENDER DIFFERENCES - TOWARDS PRECISION MEDICINE FOR BRAIN DISORDERS

Session Type
SYMPOSIUM
Date
14.03.2021, Sunday
Session Time
08:00 - 10:00
Room
On Demand Symposia B
Lecture Time
09:45 - 10:00
Session Icon
On-Demand

Abstract

Abstract Body

Sex and gender differences - towards precision medicine for brain disorders

Objectives Diagnosis and treatment of brain disorders is still largely based on clinical observation of symptoms and trial and error. However, in recent years, cumulating evidence has indicated that patient variability exists, and that pathological mechanisms are often shared between different syndromes. Precision medicine, as applied in oncology, might provide substantial progress in the field, from molecular diagnosis to tailored treatments.

Methods In this regard, sex and gender differences are emerging as leading features driving patient heterogeneity in a variety of brain diseases, including Alzheimer and Parkinson. These differences offer therefore a useful starting point to discuss potential applications of precision medicine in neurology.

Results Taking the example of Alzheimer’s Disease, in this talk I will present the latest evidence on clinically relevant sex and gender differences and their implications for basic research, clinical practice (diagnosis, prevention and treatment), clinical trial design and development of digital health technologies for AD.
Conclusions A proper understanding of sex-differences will be key towards a precision medicine paradigm in AD, beyond a ‘one size fits all’ approach.

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