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TIME TO POSITIVITY OF BLOOD CULTURES IN A PEDIATRIC HOSPITAL: A 6 YEARS’ EXPERIENCE IN BOGOTÁ, COLOMBIA
Abstract
Background
Time to positivity(TTP) is the time between the beginning of incubation and detection of growth in an automated system for blood culture. Some studies have found that TTP are related to prognosis in bacteremia. The diagnostic and prognostic value of TPP in pediatrics are related with high inoculum and small TTP, but few studies describe it.
Aims
To describe the TTP of 6 years of blood cultures in a Pediatric Hospital in Bogotá, Colombia.
Methods
We conducted a retrospective descriptive study of TTP in 6 years(2015-2020) in a Pediatric Hospital in Colombia. We obtained information of time to positivity using BD-Epicenter. We analyzed it with R4.0.3.
Results
We included 1258 blood cultures. Most frequent pathogen was coagulase-negative Staphylococci(CoNS) (409–32,5%), followed by S. aureus (264–20,9%), E. coli (176–14%), K. pneumoniae (68–5,4%), Streptococcus viridans (64-5,1%) and pneumococcus (29–2,3%). CoNS was most common in newborns and infants, and S. aureus in children and adolescents. Median TTP for S. aureus was 15 hours(IQR 12.3–18.6), E. coli 10.1 hours(IQR8.6–11.5), K. pneumoniae 9.5 hours (IQR8.3–10.9), Streptococcus viridans 14.1 hours (IQR12.1–16.1) and pneumococcus was 10.7 hours(IQR8.5-11.6). CoNS have a delayed growth (median 19.6h IQR17.1–23.2) related with contamination. TTP change the proportion of different organisms; <15 hours are frequent for pneumococcus and K. pneumoniae, >50 hours another pathogens (ie.Yeast) and contamination with CoNS are frequent.
Conclusions
TTP in pediatrics related to pathogenic isolates are practically always less that one day and common pathogens in Pediatrics usually growth in the first 14 hours. The TTP could change the probability of obtaining different pathogens.