Over the last 20 years I have been based full-time at the East Africa, where I lead a research group that have highlighted the unique importance of emergency-care research, previously poorly appreciated as an area for specific funder or policy investment, as a highly targeted and cost-effective means of tackling childhood mortality in resource-limited sub-Saharan Africa. My most notable work, as the principal investigator, was the landmark fluid resuscitation trial (FEAST trial). FEAST demonstrated that fluid boluses resulted in increased mortality in African children with severe febrile illness and excess mortality was largely a result of cardio-vascular collapse. My team recently completed the TRACT trial which tested two transfusion strategies in nearly 4000 African children that aimed to reduce deaths and illness those hospitalised with severe anaemia. Both trial papers were published in 2019 and are likely to lead to significant refinements to WHO transfusion guidelines. My team has also recently published a large controlled trial of oxygen (COAST) in Intensive Care Medicine 2021.