Welcome to the WSPID 2022 Virtual Congress Calendar

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Pre-Congress days – 20-21 February

Main Congress days – 22-24 February

 

    Fully Live Session       - Semi-live session with Live Q&A   - Voting    - On Demand Session (watch anytime)    
            

Displaying One Session

Session Type
Oral Presentations
Date
Thu, 24.02.2022
Session Time
10:00 AM - 11:00 AM
Room
Sala C
Session Icon
Pre-Recorded with Live Q&A

HEALTHCARE-ASSOCIATED INFECTIONS AMONGST NEONATES IN NON-TERTIARY HOSPITALS, SOUTH AFRICA

Session Type
Oral Presentations
Date
Thu, 24.02.2022
Session Time
10:00 AM - 11:00 AM
Room
Sala C
Session Icon
Pre-Recorded with Live Q&A
Lecture Time
10:00 AM - 10:10 AM

Abstract

Background

BackgroundBackground
In low- and middle-income countries, infection is a major contributor to neonatal mortality, and aetiological data from non-central hospitals are scarce.

Aims

We conducted enhanced laboratory surveillance for culture-confirmed bloodstream infections and meningitis among neonates aged <28days at six non-tertiary level neonatal units in South Africa

Methods

From October 2019 through September 2020, clinical data and isolate(s) were collected. Healthcare-associated-infections (HAI) were those diagnosed in a neonate aged ≥3days and hospitalised for ≥48hours prior to specimen collection.

Results

Of 933 episodes of neonatal infection, clinical data were available for 812. Of these 30% (243/812) were early-onset sepsis (EOS: aged <3days), 14% (111/812) were community-associated infections (CAI: aged >3days and hospitalised <48hours) and 56% (n=458/812) were HAI. Day 28 mortality was 21% amongst EOS, 20% amongst CAI and 29% amongst HAI (p=0.01).
259/458 (57%) HAI cases had isolates available for characterisation. Of these, 79% (205) were Gram-negative bacteria (GN), 15% (39) Gram-positive bacteria (GP) and 6% (15) fungal isolates. The top four aetiologies were Klebsiella pneumoniae (102, 39%), Acinetobacter baumannii (58, 22%), Enterobacter cloacae (19, 7%) and Staphylococcus aureus (18, 7%),
Amongst HAIs, 48% (93/195) GN and 65% (24/37) GP were susceptible to at least one first-line antibiotic (ampicillin and gentamicin). Eight-five percent (162/191) GN and 89% (32/36) of GP were susceptible to at least one second-line antibiotic (piperacillin-tazobactam and amikacin). Fifty percent (98/196) GN and 78% (28/36) GP were susceptible to meropenem.

Conclusions

Neonatal HAI was associated with a high mortality, with high prevalence of GN infections and substantial resistance to WHO-recommended antibiotic therapy.

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SEROPREVALENCE OF SARS-COV-2 IN CHILDREN IN DELHI, INDIA: A POPULATION BASED SEROEPIDEMIOLOGICAL STUDY

Session Type
Oral Presentations
Date
Thu, 24.02.2022
Session Time
10:00 AM - 11:00 AM
Room
Sala C
Session Icon
Pre-Recorded with Live Q&A
Lecture Time
10:10 AM - 10:20 AM

Abstract

Background

Globally, children and adolescents in absence of chronic underlying illnesses have been observed to experience less severe manifestations of the Covid-19 disease and low mortality hypothesized from multiple differential physiological mechanisms. However, there are growing public health concerns in India related to the extent of susceptibility in this hitherto unvaccinated and potentially vulnerable cohort.

Aims

To determine the seroprevalence of SARS-CoV-2 infection in children and adolescents and ascertain their predictors

Methods

This cross-sectional serosurvey included 4290 children aged 5-17 years and 23807 adults, and was conducted from January 11-22’ 2021. The participants were selected through a multi-stage sampling technique from all the 280 wards of the state of Delhi, India. Anti SARS CoV-2 IgG antibodies were detected by using the VITROS assay (90% Sn, 100% Sp).

Results

The seroprevalence of IgG SARS-CoV-2 in children was 52.8% (95% C.I. 51.3, 54.3) which was higher compared to adults (50.3%, 95% CI 49.7, 50.9). The assay adjusted seroprevalence in children was 53.5% (95% C.I. 51.7, 55.4). On adjusted analysis, older (15-17 years) aged compared to the younger children had significantly higher odds of infection (aOR 1.16 (0.97, 1.39)). However, child gender, presence of overcrowding, and the household income levels did not show statistically significant association with seropositivity. Among the participants with past history of laboratory diagnosed Covid-19 disease (n=102), 77 (75.5%) were also currently seropositive.

Conclusions

SARS-CoV-2 seropositivity was observed in more than one in two children. Comparable seroprevalence with adults indicates greater protection and discounts the possibility of children being disproportionately impacted during any future Covid-19 pandemic wave.

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HEALTHCARE ASSOCIATED INFECTIONS DURING THE COVID-19 PANDEMIC IN A THIRD LEVEL PEDIATRIC HOSPITAL

Session Type
Oral Presentations
Date
Thu, 24.02.2022
Session Time
10:00 AM - 11:00 AM
Room
Sala C
Session Icon
Pre-Recorded with Live Q&A
Lecture Time
10:20 AM - 10:30 AM

Abstract

Background

Since the beginning of the year 2020, the Coronavirus Disease-19 (COVID-19) pandemic has affected the world and thus, the Healthcare Systems around the world in an unprecedented way. It has been reported that the pandemic has implied an increase in the numbers of the Healthcare Associated Infections (HAIs), therefore we decided to explore the impact of the pandemic in a Third Level Pediatric Hospital in Mexico City.

Aims

Determine the prevalence of the HAIs before and after the beginning of the COVID-19 pandemic.

Methods

We realized a retrospective study from November 2018 until June 2021 using the medical records of pediatric patients with HAIs in our hospital. We included demographic data, type of infection and the microorganisms found in these HAIs. Data was analyzed in quarters of a year comparing pre-pandemic and pandemic data.

Results

Our pre-pandemic data shows a total of 825 HAIs with a rate of 8.1 per 1,000 patient-days comparing to a total of 625 HAIs with a rate of 7.3 per 1,000 patient-days. Comparison shows a 17.6% reduction in total HAIs and 10% reduction in HAIs rate per 1,00 patient-days between both time periods.

Conclusions

There is a decrease in total and rate per 1,000 patient-days of HAIs contrary to what is documented in other reports. The increase in the prevention measures and the high compliance of the Healthcare Personnel regarding these preventive measures, may have contributed to the reduction of the HAIs in our Hospital.

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PERFORMANCE OF AUTOMATED VERSUS MANUAL RESPIRATORY RATE MEASUREMENT IN CHILDREN UNDER FIVE ADMITTED WITH SUSPICION OF BLOODSTREAM INFECTION TO KISANTU HOSPITAL, DR CONGO

Session Type
Oral Presentations
Date
Thu, 24.02.2022
Session Time
10:00 AM - 11:00 AM
Room
Sala C
Session Icon
Pre-Recorded with Live Q&A
Lecture Time
10:30 AM - 10:40 AM

Abstract

Background

To improve early recognition of danger signs in children with sepsis in low resource settings, WHO promotes automated respiratory rate (RR) counting.

Aims

Prospective performance evaluation of an automated plethysmography-based RR counter in a hospital setting in sub-Saharan Africa.

Methods

RR was simultaneously measured manually (comparative method) and with Rad G pulse oximeter (Masimo, Irvine, US) (Figure 1) by a trained study nurse in children (>28 days - <5 years) admitted to Kisantu hospital with suspicion of bloodstream infection upon inclusion in the DeNTS study (NCT04473768). Rapid breathing was defined according to WHO criteria.

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Results

Paired RR measurements were correctly and successfully obtained in 206 (80.3%) eligible children, from whom 44.2% (91/206) had rapid breathing based on manual counting (Figure 2). Automated counting frequently underestimated the RR (median difference of -1 breath/ minute ; p2.5 – p97.5 limits of agreement: -34.5 – 4), particularly at higher RR (Figure 3). This resulted in failure to detect rapid breathing in nearly a quarter (21/91, 23%) of rapidly breathing children (positive percent agreement: 76.9%), while children with normal RR were mostly correctly classified (negative percent agreement: 97.3% ; kappa-statistic: 0.76). Logistic regression revealed that low hemoglobin levels were associated with failure to automatically detect rapid breathing.

210901_bt_auto rr_abstract wspid_figure2.jpg

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Conclusions

In the present setting, the automated RR counter performed insufficiently in terms of limits of agreement and positive percent agreement.

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IMPACT OF THE DUAL HIV/SYPHILIS RAPID DIAGNOSTIC TESTS IN CATALYZING CONGENITAL SYPHILIS ELIMINATION: EVIDENCE FROM ETHIOPIA AND NIGERIA

Session Type
Oral Presentations
Date
Thu, 24.02.2022
Session Time
10:00 AM - 11:00 AM
Room
Sala C
Session Icon
Pre-Recorded with Live Q&A
Lecture Time
10:40 AM - 10:50 AM

Abstract

Background

About one million pregnant women (PW) are infected with syphilis globally, leading to an estimated 350,000 adverse pregnancy outcomes annually. In Ethiopia, 45% and 90% of PW are tested for syphilis and HIV respectively during ANC, with testing rates at 16% and 66% in Nigeria. The ‘testing gap’ between HIV and syphilis represents a missed opportunity to screen and treat maternal syphilis.

Aims

CHAI supported the Governments to conduct pilots, introducing dual HIV/syphilis RDTs in ANC across 40 and 31 Health Facilities (HF) in Ethiopia and Nigeria respectively, demonstrating the dual RDT’s operational feasibility and establishing impact driving congenital syphilis elimination.

Methods

HFs with the highest first ANC attendance volume, based on a three-year retrospective DHIS data, were selected for the pilot per region/state. 1,678 health care workers in Nigeria and 159 in Ethiopia were trained to use dual RDTs and administer Benzathine Penicillin G for syphilis treatment over the 6-month and 18-month respective pilot periods in Ethiopia and Nigeria.

Results

45,413 pregnant women were tested for HIV and syphilis in Nigeria, representing 100% syphilis testing coverage. Syphilis positivity rate was 0.2%, treatment uptake 90% and partner testing 42%. In Ethiopia, 97% of the 14,568 ANC attendees were tested with the dual RDT. Syphilis positivity rate was 0.6%, treatment uptake 98%, and partner testing 75%.

Conclusions

Dual HIV/syphilis RDTs have the potential to rapidly scale up access to HIV and syphilis diagnosis for pregnant women, a key strategy and pathway towards achieving dual elimination of mother-to-child transmission of both diseases.

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COMPARISON OF ULTRAVIOLET C LIGHT TO ALCOHOL IN DISINFECTING CELLULAR PHONES TO PREVENT HEALTHCARE ASSOCIATED INFECTION IN AN ICU SETTING

Session Type
Oral Presentations
Date
Thu, 24.02.2022
Session Time
10:00 AM - 11:00 AM
Room
Sala C
Session Icon
Pre-Recorded with Live Q&A
Lecture Time
10:50 AM - 11:00 AM

Abstract

Background

Cellular phones of healthcare workers are carriers of pathogenic organisms, yet are rarely disinfected. These devices may become reservoirs to infect susceptible patients. Isopropyl alcohol-based disinfection of the phone has been advocated, but newer devices using ultraviolet C (UVC) light to disinfect cellular phones are now available. Level one evidence does not exist comparing the efficacy of UVC light with isopropyl alcohol-based swabs disinfection.

Aims

This study aims to compare the efficacy of the UVC light to 70% isopropyl alcohol-based swabs in disinfecting cellular phones.

Methods

A randomised controlled study in a paediatric ICU setting was conducted. Cellular phones of HCW or other personnel entering ICU were swabbed prior to and after decontaminating with either 70% isopropyl alcohol-based swabs or UVC light method. The reduction ratio of colony-forming units (CFU) pre-and post-intervention was analysed using the Mann-Whitney U test. In addition, the effectiveness of the decontaminant method was individually analysed using the Wilcoxon signed-rank paired test.

Results

A total of 74 cellular phones were sampled, 34 in the 70% isopropyl alcohol-based group, 35 in the UVC light group, with five exclusions. Disinfection with 70% isopropyl alcohol-based (z= 5,16; p < 0.000001) and UVC light (z = 3,28; p< 0.005) were individually statistically significant in reducing CFU of common skin commensals. When comparing isopropyl alcohol-based to UVC, isopropyl alcohol-based disinfection was superior to the UVC disinfection (p<0.001), effect size 0.67.

Conclusions

Disinfecting cellular phones with 70% isopropyl alcohol is superior to using UVC light.

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