Royal Melbourne Hospital
Neurology
Bernard Yan is Academic Professor of Neurology at the University of Melbourne. He is the President of the Stroke Society of Australasia which is the foremost society which links all stroke researchers of Australasia. He is a practicing clinical Neurologist and Endovascular Neurointerventionist in Royal Melbourne Hospital, Australia. His clinical expertise is in stroke intervention. His major research interest is in large clinical trials especially on the topic of acute endovascular clot retrieval (thrombectomy), machine learning applications in different subspecialty fields of neurology. He supervises together with the Engineering Department many PhD research students on wireless accelerometry and applications in a broad range of neurological diseases including epilepsy and stroke. Bernard Yan’s clinical trial papers include 4 published in the New England Journal of Medicine. These 4 papers have a major impact in changing stroke management guidelines. He is the founding organizer of the Australia and China Training Initiative of Neurology (ACTION) programme. The programme is in its 11th year of operations and has successfully trained over 300 young neurologists from China. He is one of the founding directors of the Australasian Stroke Academy which is the leading provider of stroke medicine education to young doctors in Australia.

Moderator Of 1 Session

Session Type
Debate
Date
28.10.2021, Thursday
Session Time
10:00 - 11:30
Room
DEBATES
Session Icon
Live Session, Voting

Presenter Of 2 Presentations

A RANDOMIZED CONTROLLED TRIAL OF DIRECT ENDOVASCULAR CLOT RETRIEVAL VERSUS STANDARD BRIDGING THROMBOLYSIS WITH ENDOVASCULAR CLOT RETRIEVAL WITHIN 4.5 HOURS OF STROKE ONSET

Session Type
Plenary Session
Date
28.10.2021, Thursday
Session Time
11:30 - 13:30
Room
PLENARY
Lecture Time
12:50 - 13:00

DIRECT MECHANICAL THROMBECTOMY VERSUS BRIDGING THERAPY FOR ACUTE ISCHAEMIC STROKE–A CUMULATIVE STUDY-LEVEL META-ANALYSIS OF THE DIRECT-MT, MRCLEAN-NOIV, DEVT, SKIP AND SWIFT-DIRECT RCTS: PLACEHOLDER ABSTRACT

Session Type
Free Communication Session
Date
29.10.2021, Friday
Session Time
15:15 - 16:45
Room
FREE COMMUNICATIONS A
Lecture Time
16:15 - 16:25

Abstract

Background and Aims

Whether direct mechanical thrombectomy (MT) in acute ischaemic stroke patients with large vessel occlusion (LVO) is equally effective as intravenous thrombolysis (IVT) with alteplase followed by MT remains a matter of debate. Primary aim of this study was to test non-inferiority of direct mechanical thrombectomy using summary estimates of study-level aggregate data of all randomized controlled trials evaluating direct MT vs IVT followed by MT. Secondary aims included superiority testing of IVT followed by MT versus direct MT and presentation of relevant secondary outcomes.

Methods

We performed a PROSPERO registered, prespecified, systematic review of electronic databases (Web of Science, PubMed, Embase) and meta-analysis with data presentation adherent to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Random effects models were used to pool the study-level data. The primary outcome used for non-inferiority and superiority testing was good functional outcome at 90 days (mRS≤2). The non-inferiority margin was prespecified. Secondary outcomes included excellent functional outcome (mRS≤1), mortality, symptomatic intracranial haemorrhage (sICH), successful reperfusion (TICI≥2b) and procedure-related complications. Five RCTs comprising 2043 patients (xy dMT, yx bridging therapy) were included.

Results

To be determined.

Conclusions

To be determined.

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