Danylo Halytsky Lviv National Medical University
Pathological Anatomy
Liliya Volos Prof. Liliya Volos was born in 1969 in Lviv, Ukraine and graduated from the Medical Faculty of the of Donetsk National Medical University in1996 (Ukraine). PhD Student of Department of Pathology and Winner of Grant of International Soros Science Educational Program for PhD students. The diploma of the Candidate of science (PhD) issued by High attestation commission of Ukraine in 1997. Her residency was at Department of Pathology and its affiliated Clinic Hospital, and she completed her training with fellowships at the Donetsk National Medical University in pathology and neuropathology. She obtained her medical degree of doctor of medical science at Bogomolets National Medical University in Kyiv in 2004. The diploma of the Professor issued by Ministry of Education and Science of Ukraine in 2007. From 2015 until the present day is professor of Department of Pathological Anatomy in Danylo Halytsky Lviv National Medical University. Prof. Liliya Volos has twenty years’ experience in pathology, with special interest in neuropathology. Proactive lecturer and researcher with 10+ years of experience teaching courses on undergraduate and postgraduate levels. Supervised 21 student theses and 5 PhD dissertations. Edited and co-authors 5 monographs on contemporary trends in neuro- and oncopathology. Published over 70 articles in peer-reviewed journals in Ukraine and other countries. She has presented oral presentations and posters and delivered invited lectures at numerous national and international stroke and neuropathology congresses. Prof. Liliya Volos is a member of the International Academy of Pathology (USA), board certified and re-certified by the Ukrainian Board of Pathology, and a member of Ukrainian Association of Pathology. Prof. Liliya Volos resides in Lviv, with her son and father. Unfortunately, husband died in 2015 in Donetsk when the war began.

Presenter of 1 Presentation

STROKE IN COVID-19-POSITIVE PATIENTS: HISTOPATHOLOGICAL FINDINGS

Session Type
Free Communication Session
Date
28.10.2021, Thursday
Session Time
15:45 - 17:15
Room
FREE COMMUNICATIONS A
Lecture Time
15:55 - 16:05

Abstract

Background and Aims

Аccording to WHO as of 17 May 2021, there have been 162 704 139 confirmed cases of COVID-19, including 3 374 052 deaths in the world. The last updated on May 17, 2021 for Ukraine indicates that coronavirus cases were 2,156,000 and deaths were 48,184. Stroke is the most difficult neurological disorder associated with COVID-19. The aim of this study was to assess the histopathological findings of the brain tissue in patients who died from complications of COVID-19 and stroke.

Methods

All patients died in Lviv regional and city hospitals from complications of COVID-19 and had a positive test for SARS-CoV-2 detected by qRT-PCR reaction. Patients were autopsied between March 2020 and May 2021, information from the autopsy protocol included macroscopic and microscopic characteristics of brain and general autopsy findings. We used common histological methods of staining with hematoxylin and eosin.

Results

The post-mortem study included 89 cases. The patients had a median age of 67 years (range, 21-97 years), 53,93% men (n=48). The majority of patients (60,67%, n=54) had hypertension, while 29 (32,58%) had type 2 diabetes mellitus and hypertension. The large vessel ischemic strokes with colliquation necrosis, inflammation infiltrates, acute hypoxic neurons and marked edema diagnosed in 3 (3,37%) COVID-19 patients, without prior history of stroke, 2 (2,25%) COVID-19 patients had evidence of intracranial hemorrhage, one of intracranial hemorrhages occurred as a secondary transformation of an ischemic infarct.

Conclusions

Stroke is the difficult neurological disorder associated with COVID-19, hypertension and diabetes are risk factors for severe COVID-19 course or poor outcome.

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