Abstract Body

The aim. To assess the variation of metabolic biomarkers in young people (apoB atherogenic particles and apoA-I antiatherogenic particles).

Materials and methods. A cross-sectional study of 88 young apparently healthy individuals, 23 (26.1%) men and 65 (73.9%) women with the mean age 19.3±0.2 (17 to 25 age range), predominantly from a rural area (78,4%). The data on demographic and social characteristics of participants were collected, and clinical examination performed. The blood samples were collected under standard conditions. The plasma total cholesterol (TC) was measured using an enzymatic method, the LDL-C was calculated according to Friedewald’s formula. The apoA-I and apoB concentrations were measured using the immunoturbidimetric method.

Results. The HDL level was 1,55±0,037 and LDL-C – 2, 29±0,05 mmol/L, and both of them increase with age in male and female (p<0.05). The levels of apoA-I varied within 0,66–3,98 g/l, the mean apoA-I values being 1,12±0,019 g/l, with fluctuations depending on sex: 0,95±0,034 g/l in males versus 0,39±0,049 g/l females (p<0,05). The mean level of apo B was 0,50±0,016 g/l, with variance between 0,01 g/l to 3,25 g/l, with significantly lower level in males 0,46±0,024 g/l versus 0,51±0,049 g/l (p<0,05). The mean of apo B/apoA-I ratio was 0,46±0,024, and it increased with age in females (p<0,05) and decreased in males (p<0,05).

Conclusion. The studied biomarkers have a tendency to increase in concentration with age and have demonstrated more “protective”, profiles in young females. However, longitudinal studies are needed to evaluate the role of their value estimated in young people to predict the cardiovascular events in adulthood.