Shirida Imami (Netherlands)
LUMC, Leiden, the Neterlands Public Health and Primary CareAuthor Of 1 Presentation
SUDDEN DEATH IN GENERAL PRACTICE AND GENETICS
Abstract
Abstract Body
Background: There is a knowledge gap regarding etiology and potential genetic cause in sudden cardiac death (SCD) among individuals who appear healthy before the event in the general practice.
Purpose: To describe causes of SCD and the potential for a genetic association in apparently healthy patients in the general practice population in Leiden, the Netherlands.
Methods: Patients were recruited from the database of the department of Pathology of the Leiden University Medical Centre from December 2008 to December 2018. A textual search was applied for “heart*”,” sudden”, *card*”, “OHCA”, “out of hospital”, “cardiac” and “arrest” in the autopsy reports. Of included cases the complete autopsy report was read, and cause of death retrieved. Cases with non-cardiac death or congenital heart disease were excluded. Cases were then analyzed by in-hospital (IHCA) or out-of-hospital cardiac arrest (OHCA) and further categorized to cardiomyopathy (CMP), coronary (CHD) or electric heart disease (EHD) or sudden unexplained cardiac death (SUD).
Results: Of 1177 cases, 96 (8%) cases with SCD were analyzed according to OHCA vs. IHCA; (67;70% vs. 29; 30%, p<0.001). Mean age was <50 yrs. (47.8 yrs. in OHCA vs. 49.7 yrs. in OHCA, respectively p=0.75). CHD was present in 31(46%) OHCA vs. 12(42%) IHCA cases (p=NS); CMP in 7 (10%) vs. 15 (52%), p<0.001; EHD 1(2%) vs. 1(3%), p=NS) and SUD 28 (42%) vs. 1 (3%), p<0.001). In SUD a genetic cause was suspected in 5/28 (18%) of cases.
Conclusion: SCD was more frequent in OHCA (p<0.001). In SUDs a genetic cause was suspected in 18% of cases.
Presenter of 1 Presentation
SUDDEN DEATH IN GENERAL PRACTICE AND GENETICS
Abstract
Abstract Body
Background: There is a knowledge gap regarding etiology and potential genetic cause in sudden cardiac death (SCD) among individuals who appear healthy before the event in the general practice.
Purpose: To describe causes of SCD and the potential for a genetic association in apparently healthy patients in the general practice population in Leiden, the Netherlands.
Methods: Patients were recruited from the database of the department of Pathology of the Leiden University Medical Centre from December 2008 to December 2018. A textual search was applied for “heart*”,” sudden”, *card*”, “OHCA”, “out of hospital”, “cardiac” and “arrest” in the autopsy reports. Of included cases the complete autopsy report was read, and cause of death retrieved. Cases with non-cardiac death or congenital heart disease were excluded. Cases were then analyzed by in-hospital (IHCA) or out-of-hospital cardiac arrest (OHCA) and further categorized to cardiomyopathy (CMP), coronary (CHD) or electric heart disease (EHD) or sudden unexplained cardiac death (SUD).
Results: Of 1177 cases, 96 (8%) cases with SCD were analyzed according to OHCA vs. IHCA; (67;70% vs. 29; 30%, p<0.001). Mean age was <50 yrs. (47.8 yrs. in OHCA vs. 49.7 yrs. in OHCA, respectively p=0.75). CHD was present in 31(46%) OHCA vs. 12(42%) IHCA cases (p=NS); CMP in 7 (10%) vs. 15 (52%), p<0.001; EHD 1(2%) vs. 1(3%), p=NS) and SUD 28 (42%) vs. 1 (3%), p<0.001). In SUD a genetic cause was suspected in 5/28 (18%) of cases.
Conclusion: SCD was more frequent in OHCA (p<0.001). In SUDs a genetic cause was suspected in 18% of cases.