IMPACT OF CHARLSON COMORBIDITY INDEX FOR IN-HOSPITAL MORTALITY FOR PATIENTS WITH ALZHEIMER’S DISEASE ADMITTED BY BEHAVIORAL AND PSYCHOLOGICAL SYMPTOMS OF DEMENTIA: PROPENSITY-SCORE-MATCHING STUDY.
Abstract
Objectives
With the growing number of patients with dementia, the number of patients who need hospitalization due to behavioral and psychological symptoms of dementia (BPSD) and somatic comorbidities is also growing. However, the factors in association with in-hospital mortality for patients with Alzheimer’s disease admitted by BPSD is unclear.
Methods
We analyzed the records of 147 inpatients diagnosed with dementia and hospitalized due to BPSD between January 2015 and December 2016. The subjects were divided into two groups based on Charlson comorbidity index score. Propensity-score matching was used to adjust for potential confounders. Outcome was judged as in-hospital death. COX proportional hazard analyses and Kaplan-Meier survival analysis were performed.
Results
After matching to demographic and clinical confounders, 88 matched pair were selected for the analysis. Twenty six subjects reached the endpoint. The cumulative incidence was significantly higher in the subjects with Charlson comorbidity index score of 2> (Log rank test, p<0.005). Analysis with a proportional hazard model showed that Charlson comorbidity index score of 2> was related to a higher risk of reaching the endpoint (HR 3.36, 95%CI 1.40-8.05, p<0.01).
Conclusions
After adjusting for important clinical predictors, Charlson comorbidity index score of 2> was associated with increased in-hospital mortality for patients with dementia admitted by BPSD.
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