Welcome to the 22nd WCP Congress Program Scheduling

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RECORDED LECTURES

Icon Legend: Pre-Recorded & Scheduled On-Demand  

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Displaying One Session

SPECIAL SESSION
Session Type
SPECIAL SESSION
Date
Thu, 04.08.2022
Session Time
17:50 - 18:50
Room
BHIRAJ HALL 1 - LIVE STREAMED

THE CURRENT STATUS OF TARDIVE DYSKINESIA

Date
Thu, 04.08.2022
Session Time
17:50 - 18:50
Session Type
SPECIAL SESSION
Lecture Time
17:50 - 18:10
Room
BHIRAJ HALL 1 - LIVE STREAMED

Abstract

Abstract Body

Tardive dyskinesia (TD) is a delayed onset movement disorder associated with the long-term use of dopamine antagonists. The typical manifestation is of choreo-athetoid movements affecting the oral, lingual, buccal, and facial musculature, although any striated muscle group may be affected, and the movements may be dystonic, stereotypic, or tic-like in some cases. This has led to the subcategorisation of TD into sub-syndromes, and a debate between lumpers and splitters. The epidemiology of TD is best documented in relation to first-generation antipsychotics, and several risk and protective factors have been described. The risk is much lower with second-generation antipsychotics, but no drug is free of the risk, with the possible exception of clozapine. The pathophysiology of TD is incompletely understood, with dopamine supersensitivity and neuronal degeneration, and a combination of the two, being the prevalent hypotheses. There is no consistently effective treatment, and prevention remains the best strategy that should be incorporated into any treatment plan involving the longer-term use of dopamine antagonists. Drug treatment of TD is symptomatic, and any benefit needs to be balanced against adverse effects. There has been much recent interest in vesicular monoamine transporter 2 (VMAT2) inhibitors, with three such drugs – tetrabenazine, deutetrabenazine, and valbenazine – having been shown to have beneficial effects in controlled studies. Other strategies include the use of GABAergic drugs, switching to clozapine, use of botulinum toxin, medical cannabis, and the rare use of ECT and deep brain stimulation.

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PSYCHOTROPIC INDUCED TARDIVE SYNDROMES - AN OVERVIEW

Date
Thu, 04.08.2022
Session Time
17:50 - 18:50
Session Type
SPECIAL SESSION
Lecture Time
18:10 - 18:30
Room
BHIRAJ HALL 1 - LIVE STREAMED

Abstract

Abstract Body

Tardive Syndromes encompass persistent hyperkinetic, hypokinetic and sensory phenomenologies resulting from chronic dopamine receptor blocking agents (DRBA) exposure. Apart from tardive dyskinesia the spectrum involves tardive dystonia, tardive akathisia, tardive tremor, tardive tourettism, tardive myoclonus, tardive pain and tardive ocular deviations. The incidence of TS is estimated to increase linearly by 5% annually during the first 5 years, 49% after 10 years, and 68% after 25 years whereas the global mean prevalence is around 25.3%.The symptoms of TS typically emerge after 1-2 years of continuous exposure to a DRBA and almost never before 1-3 months. Remission rates are below 25%.
The presentation focuses on diverse types of tardive syndromes and the management principles
Further reading
Bhidayasiri R &, Boonyawairoj S (2011) Spectrum of tardive syndromes: clinical recognition and management. Postgrad Med J 87(1024):132-41.

Factor SA (2020) Management of Tardive Syndrome: Medications and Surgical Treatments Neurotherapeutics 17(4):1694-1712.

Factor SA et al (2019) Recent developments in drug-induced movement disorders: a mixed picture Lancet Neurol 18(9):880-890.
Saifee TA & Edwards MJ (2011) Tardive movement disorders: a practical approach Practical Neurology; 11:341–348.
Savitt D &, Jankovic J (2018) .Tardive syndromes. J Neurol Sci, 389:35-42.
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THE PSYCHOMOTOR DIMENSION OF PSYCHOSIS AND PSYCHOTROPIC-INDUCED MOTOR SYNDROMES: RELATIONSHIP AND DIFFERENTIATION

Date
Thu, 04.08.2022
Session Time
17:50 - 18:50
Session Type
SPECIAL SESSION
Lecture Time
18:30 - 18:50
Room
BHIRAJ HALL 1 - LIVE STREAMED