Pedro Antonio P. Jesus (Brazil)
Author Of 1 Presentation
POST-STROKE DELIRIUM IN YOUNGER PATIENTS IS ASSOCIATED WITH WORSE CLINICAL PRESENTATION AND FUNCTIONAL DISABILITY
- Daniel G. Silva (Brazil)
Abstract
Background and Aims:
Introduction: Post-stroke delirium is a common syndrome in the elderly. However, younger patients are less likely to develop it and recognized for favorable clinical outcomes after stroke. Objective: Evaluate the impact of delirium on prognosis of stroke patients in different age groups.
Methods:
Methods: Prospective cohort of patients admitted to a stroke unit from 2017 to 2020. Delirium was diagnosed by using CAM-ICU. Patients with delirium were divided into > 65 years and ≤ 65 years and compared to non-delirium patients. The main outcome was mRs > 2 in 90 days post-stroke.
Results:
Results: 444 patients were enrolled. Delirium occurred in 114 patients (25.7%), of which 78 were elderly and 36 were ≤ 65 years. Although they had fewer comorbidities, younger patients affected by delirium had higher NIHSS scores than elderly and non delirium patients [Mean (±SD) = 13(±4) vs 10(±8) vs 8(±7); p < 0.001] and lower ASPECTS scores [Median(IIQ)= 8(6.75-9.00) vs 9(6.25-9.75) vs 9(8.00-10.00); p < 0.001]. In multivariate analysis, delirium in younger people was a predictor of mRS > 2 in 90 days [OR= 4.58; (95% CI 1.57-13.36)], while its occurrence in the elderly was not associated with worse outcomes [OR= 1,84; (CI 95% 0,76-4,47)].
Conclusions:
Conclusion: Although delirium is less frequent in younger people, it is associated with worse prognosis. We suggest that severe strokes may have a major role in younger patients’ delirium and helps to understand our results. This is the first work to investigate the influence of post-stroke delirium in the non-elderly patient population.