Justin Lapow (United States of America)
New York Medical College School of MedicineAuthor Of 1 Presentation
OBSTRUCTIVE SLEEP APNEA CONFERS LOWER MORTALITY RISK IN ACUTE ISCHEMIC STROKE PATIENTS TREATED WITH ENDOVASCULAR THROMBECTOMY: NATIONAL INPATIENT SAMPLE ANALYSIS 2010-2018
- Justin Lapow (United States of America)
Abstract
Background and Aims:
Obstructive Sleep Apnea (OSA) has previously been shown to portend increased morbidity and mortality following acute ischemic stroke (AIS). Evaluation of OSA in the setting of AIS treated with endovascular mechanical thrombectomy (MT) has not yet been evaluated in the literature.
Methods:
The National Inpatient Sample was queried from 2010-2018 to identify adult AIS patients treated with MT. Those with and without OSA were compared on the basis of clinical characteristics, complications, and discharge disposition. Multivariable logistic regression analysis was employed to evaluate independent associations between OSA and clinical outcome.
Results:
Among 101,093 AIS patients treated with MT identified in our analysis, 6,412 (6.3%) had OSA. The OSA group had significantly higher rates of obesity (41.4% vs. 10.5%, p < 0.001), atrial fibrillation (47.1% vs. 42.2%, p = 0.001), hypertension (87.4% vs. 78.5%, p < 0.001), and diabetes mellitus (41.2% vs. 26.9%, p < 0.001). OSA patients treated with MT demonstrated lower rates of intracranial hemorrhage (19.1% vs. 21.8%, p = 0.017), treatment of hydrocephalus (0.3% vs. 1.1%, p = 0.009), and in-hospital mortality compared to non-OSA patients (9.7% vs. 13.5%, p < 0.001). In a multivariable logistic regression model controlling for age, acute illness and stroke severity, and comorbid conditions, OSA status was independently associated with in-hospital mortality (OR = 0.78, 95% CI = 0.63-0.96, p = 0.020).
Conclusions:
OSA was found to be independently associated with in-hospital mortality after treatment of AIS with MT. Our findings suggest MT is a viable and safe treatment option for AIS patients with OSA.
Presenter of 1 Presentation
OBSTRUCTIVE SLEEP APNEA CONFERS LOWER MORTALITY RISK IN ACUTE ISCHEMIC STROKE PATIENTS TREATED WITH ENDOVASCULAR THROMBECTOMY: NATIONAL INPATIENT SAMPLE ANALYSIS 2010-2018
- Justin Lapow (United States of America)
Abstract
Background and Aims:
Obstructive Sleep Apnea (OSA) has previously been shown to portend increased morbidity and mortality following acute ischemic stroke (AIS). Evaluation of OSA in the setting of AIS treated with endovascular mechanical thrombectomy (MT) has not yet been evaluated in the literature.
Methods:
The National Inpatient Sample was queried from 2010-2018 to identify adult AIS patients treated with MT. Those with and without OSA were compared on the basis of clinical characteristics, complications, and discharge disposition. Multivariable logistic regression analysis was employed to evaluate independent associations between OSA and clinical outcome.
Results:
Among 101,093 AIS patients treated with MT identified in our analysis, 6,412 (6.3%) had OSA. The OSA group had significantly higher rates of obesity (41.4% vs. 10.5%, p < 0.001), atrial fibrillation (47.1% vs. 42.2%, p = 0.001), hypertension (87.4% vs. 78.5%, p < 0.001), and diabetes mellitus (41.2% vs. 26.9%, p < 0.001). OSA patients treated with MT demonstrated lower rates of intracranial hemorrhage (19.1% vs. 21.8%, p = 0.017), treatment of hydrocephalus (0.3% vs. 1.1%, p = 0.009), and in-hospital mortality compared to non-OSA patients (9.7% vs. 13.5%, p < 0.001). In a multivariable logistic regression model controlling for age, acute illness and stroke severity, and comorbid conditions, OSA status was independently associated with in-hospital mortality (OR = 0.78, 95% CI = 0.63-0.96, p = 0.020).
Conclusions:
OSA was found to be independently associated with in-hospital mortality after treatment of AIS with MT. Our findings suggest MT is a viable and safe treatment option for AIS patients with OSA.