Ryuji Sakakibara (Japan)

Sakura Medical Center, Toho University Neurology
Dr. Ryuji Sakakibara was born and raised in Japan. He received his medical degree from the Asahikawa Medical College in 1984. Because of interest in clinical neurology, he moved forward to Chiba University where he subsequently worked as an assistant Professor, and a Lecturer in the Department of Neurology. He completed his Ph.D. at the Department of Neurology, Chiba University, in 1992 (Professor Takamichi hattori). From 1997 to 1998 he was a research fellow in the National Hospital for Neurology and Neurosurgery / Institute of Neurology, Queen Square, London, supervised by Professor Clare J. Fowler in the Department of Uro-Neurology. In 2007 March, he started a new Department of Neurology in Toho University, Sakura Medical Center, Sakura, Japan as an associate Professor, and as the Professor and Chair in 2016. He is a member of many international societies including the American Academy of Neurology, the Association of British Neurologists, the Movement Disorders Society, the International Society for Autonomic Neuroscience, and the International Continence Society. During his career, Dr. Sakakibara has authored more than 300 articles in peer-reviewed international journals. SYNOPSIS OF AREA OF INTEREST: Dr. Sakakibara's research interests include neuro-urology, neuro-gastroenterology, autonomic physiology, drug trials and clinical neurology including Parkinson’s disease and multiple system atrophy.

Author Of 1 Presentation

Scientific Session: MT (Main Topics)

GASTROINTESTINAL DYSFUNCTION IN NEUROINFLAMMATORY DISEASES

Session Type
Scientific Session: MT (Main Topics)
Date
03.10.2021, Sunday
Session Time
09:30 - 11:00
Room
Main Topic B
Lecture Time
10:16 - 10:39
Presenter
  • Ryuji Sakakibara (Japan)

Abstract

Abstract Body

Nervous system has ‘guts’ to produce a variety of gastrointestinal (GI) dysfunction. Among these, focal brain disease causes appetite loss (hypothalamus), decreased peristalsis (presumably the basal ganglia, pontine defecation center/ Barrington’s nucleus), decreased abdominal strain (presumably parabrachial nucleus/ Kolliker-Fuse nucleus), hiccup and vomiting (area postrema/ dorsal vagal complex); spinal cord disease causes decreased peristalsis and anismus (tracts, the intermediolateral nucleus) (CNS); and disease affecting the peripheral nerve including the myenteric plexus causes decreased peristalsis with/without loss of bowel sensation (PNS).

Recently inflammatory causes of the nervous diseases, particularly those affecting the PNS, are being recognized to contribute to GI dysfunction of previously-unknown etiology. We briefly review neuroinflammatory diseases that potentially cause GI dysfunction, e.g., multiple sclerosis, neuromyelitis optica spectrum disorder (anti-aquaporin 4 or MOG antibody), autoimmune acute myelitis, subacute disseminated encephalomyelitis, and autoimmune encephalitis (anti-NMDA glutamate receptor antibody etc.) (CNS); Guillain-Barre syndrome (anti-ganglioside antibody etc.), acute sensory-autonomic neuropathy/ acute pandysautonomia (anti-nicotinic ganglionic acetylcholine receptor [gAChR] antibody), pure autonomic failure (anti-gAChR antibody in some), paraneoplastic sensory-autonomic neuropathy (anti-Hu, CRPMP5, gAChR, VGKC antibody etc.), (selective organs) paraneoplastic/idiopathic intestinal pseudo-obstruction and achalasia (anti-gAChR antibody in some), and collagen diseases affecting both CNS and PNS (Sjogren syndrome, scleroderma, etc.).

These GI dysfunctions may occur solely, predate, or occur concurrent with other nervous system symptoms. Such patients may visit gastroenterologists or physicians first before the correct diagnosis was made. Therefore, collaboration of gastroenterologists and neurologists are highly recommended in order for the early diagnosis and optimal management.

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Presenter of 1 Presentation

Scientific Session: MT (Main Topics)

GASTROINTESTINAL DYSFUNCTION IN NEUROINFLAMMATORY DISEASES

Session Type
Scientific Session: MT (Main Topics)
Date
03.10.2021, Sunday
Session Time
09:30 - 11:00
Room
Main Topic B
Lecture Time
10:16 - 10:39
Presenter
  • Ryuji Sakakibara (Japan)

Abstract

Abstract Body

Nervous system has ‘guts’ to produce a variety of gastrointestinal (GI) dysfunction. Among these, focal brain disease causes appetite loss (hypothalamus), decreased peristalsis (presumably the basal ganglia, pontine defecation center/ Barrington’s nucleus), decreased abdominal strain (presumably parabrachial nucleus/ Kolliker-Fuse nucleus), hiccup and vomiting (area postrema/ dorsal vagal complex); spinal cord disease causes decreased peristalsis and anismus (tracts, the intermediolateral nucleus) (CNS); and disease affecting the peripheral nerve including the myenteric plexus causes decreased peristalsis with/without loss of bowel sensation (PNS).

Recently inflammatory causes of the nervous diseases, particularly those affecting the PNS, are being recognized to contribute to GI dysfunction of previously-unknown etiology. We briefly review neuroinflammatory diseases that potentially cause GI dysfunction, e.g., multiple sclerosis, neuromyelitis optica spectrum disorder (anti-aquaporin 4 or MOG antibody), autoimmune acute myelitis, subacute disseminated encephalomyelitis, and autoimmune encephalitis (anti-NMDA glutamate receptor antibody etc.) (CNS); Guillain-Barre syndrome (anti-ganglioside antibody etc.), acute sensory-autonomic neuropathy/ acute pandysautonomia (anti-nicotinic ganglionic acetylcholine receptor [gAChR] antibody), pure autonomic failure (anti-gAChR antibody in some), paraneoplastic sensory-autonomic neuropathy (anti-Hu, CRPMP5, gAChR, VGKC antibody etc.), (selective organs) paraneoplastic/idiopathic intestinal pseudo-obstruction and achalasia (anti-gAChR antibody in some), and collagen diseases affecting both CNS and PNS (Sjogren syndrome, scleroderma, etc.).

These GI dysfunctions may occur solely, predate, or occur concurrent with other nervous system symptoms. Such patients may visit gastroenterologists or physicians first before the correct diagnosis was made. Therefore, collaboration of gastroenterologists and neurologists are highly recommended in order for the early diagnosis and optimal management.

Hide