Ruihao Wang (Germany)

University of Erlangen-Nuremberg Department of Neurology
Dr. Ruihao Wang studied medicine at Zhengzhou University (China) and graduated in July 2013 with both Bachelor and Master Degrees in Medicine. After that he did clinical research on the autonomic nervous system at the Department of Neurology, University of Erlangen-Nuremberg (Germany) following the supervision of Prof. M. Hilz, he got the doctorate Dr. med. in October 2017. He then did post-doc research for about one year and since December 2018 becomes a resident at the Department of Neurology, University Hospital Erlangen until now. His research interests focus on the autonomic nervous system in various neurological disorders including traumatic brain injury, multiple sclerosis, ischemic and hemorrhagic stroke, and epilepsy etc., as well as clinical studies regarding stroke induced heart injuries. Currently he is still during the so called “Facharztausbildung” process and tries to become a neurologist (Facharzt für Neurologie). The goal of Dr. Wang is to master the clinical routine work and to carry on with the clinical research.

Author Of 1 Presentation

 Conference Calendar
Free Communication

CARDIOVASCULAR AUTONOMIC DYSFUNCTION IN PATIENTS WITH POSTERIOR CIRCULATION ISCHEMIC STROKE

Session Type
Free Communication
Session Name
1390 - FREE COMMUNICATION: Autonomic Nervous System & Autoimmune Disorders (ID 212)
Date
06.10.2021, Wednesday
Session Time
11:30 - 13:00
Room
Free Communication B
Lecture Time
11:30 - 11:40
Presenter
  • Ruihao Wang (Germany)

Abstract

Background and Aims:

Although it is well known that ischemic stroke may cause cardiovascular autonomic dysfunction, most studies focus on patients with anterior circulation stroke. In patients with posterior circulation ischemic stroke (PCIS), cardiovascular autonomic modulation has only been rarely studied. Therefore, we aimed to assess cardiovascular autonomic modulation in PCIS patients.

Methods:

In 57 patients with PCIS (12 occipital lobe, 14 thalamic, 11 cerebellar, 20 brainstem strokes) and 30 age- and gender-matched controls, we recorded RR-intervals (RRI), systolic, diastolic blood pressures (BPsys, BPdia), and respiration (RESP) at supine rest, within one week after stroke-onset. We calculated parameters reflecting total cardiac autonomic modulation [RRI-standard-deviation (RRI-SD), RRI-total-powers], mainly or exclusively sympathetic [RRI-low-frequency-powers (RRI-LF-powers) and BPsys-LF-powers] and parasympathetic cardiovascular modulation [Root-Mean-Square-of-Successive-RRI-Differences (RMSSD), RRI-high-frequency-powers (RRI-HF-powers)], sympathetic-parasympathetic balance (RRI-LF/HF-ratios), and baroreflex-sensitivity (BRS). Values were compared with one-way ANOVA or Kruskal-Wallis-Test, with post-hoc analyses. Significance was assumed for p<0.05.

Results:

In the patients of all PCIS- subgroups, values of RRI, RRI-SD, RMSSD, RRI-HF-powers, and BRS were significantly lower, while BPsys-LF-powers were higher than in the controls. In patients with ischemia in the occipital lobe, RRI-LF/HF-ratios were significant higher than in controls. Autonomic parameters did not differ between PCIS-subgroups.

Conclusions:

Within one week after PCIS-onset, patients have reduced parasympathetic and increased sympathetic cardiovascular modulation with diminished BRS. These findings are similar to our previous findings in patients after acute ischemic stroke in the middle cerebral artery territory (Hilz et al. 2011). The shift towards sympathetic predominance seems to be more pronounced in patients with occipital lobe lesions.

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Presenter of 1 Presentation

 Conference Calendar
Free Communication

CARDIOVASCULAR AUTONOMIC DYSFUNCTION IN PATIENTS WITH POSTERIOR CIRCULATION ISCHEMIC STROKE

Session Type
Free Communication
Session Name
1390 - FREE COMMUNICATION: Autonomic Nervous System & Autoimmune Disorders (ID 212)
Date
06.10.2021, Wednesday
Session Time
11:30 - 13:00
Room
Free Communication B
Lecture Time
11:30 - 11:40
Presenter
  • Ruihao Wang (Germany)

Abstract

Background and Aims:

Although it is well known that ischemic stroke may cause cardiovascular autonomic dysfunction, most studies focus on patients with anterior circulation stroke. In patients with posterior circulation ischemic stroke (PCIS), cardiovascular autonomic modulation has only been rarely studied. Therefore, we aimed to assess cardiovascular autonomic modulation in PCIS patients.

Methods:

In 57 patients with PCIS (12 occipital lobe, 14 thalamic, 11 cerebellar, 20 brainstem strokes) and 30 age- and gender-matched controls, we recorded RR-intervals (RRI), systolic, diastolic blood pressures (BPsys, BPdia), and respiration (RESP) at supine rest, within one week after stroke-onset. We calculated parameters reflecting total cardiac autonomic modulation [RRI-standard-deviation (RRI-SD), RRI-total-powers], mainly or exclusively sympathetic [RRI-low-frequency-powers (RRI-LF-powers) and BPsys-LF-powers] and parasympathetic cardiovascular modulation [Root-Mean-Square-of-Successive-RRI-Differences (RMSSD), RRI-high-frequency-powers (RRI-HF-powers)], sympathetic-parasympathetic balance (RRI-LF/HF-ratios), and baroreflex-sensitivity (BRS). Values were compared with one-way ANOVA or Kruskal-Wallis-Test, with post-hoc analyses. Significance was assumed for p<0.05.

Results:

In the patients of all PCIS- subgroups, values of RRI, RRI-SD, RMSSD, RRI-HF-powers, and BRS were significantly lower, while BPsys-LF-powers were higher than in the controls. In patients with ischemia in the occipital lobe, RRI-LF/HF-ratios were significant higher than in controls. Autonomic parameters did not differ between PCIS-subgroups.

Conclusions:

Within one week after PCIS-onset, patients have reduced parasympathetic and increased sympathetic cardiovascular modulation with diminished BRS. These findings are similar to our previous findings in patients after acute ischemic stroke in the middle cerebral artery territory (Hilz et al. 2011). The shift towards sympathetic predominance seems to be more pronounced in patients with occipital lobe lesions.

Hide