Background and Aims:

Background: Parkinson's Disease (PD) patients suffer from a wide range of motor symptoms and PD motor subtypes, including tremor‐dominant (TD) and non‐tremor dominant (nTD) (characterized by postural instability and gait difficulty and known as PIDG) have been described. Heterogeneity have been observed in non-motor symptoms of PD patients, but reports on this topic are conflicting.

Aim: We aimed to investigate autonomic dysfunction in PD motor subtypes by scales for outcomes in PD-autonomic symptoms (SCOPA-AUT).

Methods:

Methods: 46 Non demented PD patients (28 men and 18 women; mean patient’s age 65.1± 9.5; 46% in Hoehn–Yahr stage 1, mean disease duration 3.8 years) were grouped into TD, indeterminant, and PIGD subtypes. Motor and non-motor parameters were analysed at baseline and after 4 years of follow up periods.

Results:

Results: Among our cohort, 22 patients were classified as TD, 5 patients as indeterminant type and 19 patients as PIGD type. At follow-up, 25 patients were classified as PIGD type, 5 as indeterminant type, 16 as TD. At baseline SCOPA-AUT score was higher in PIGD than the subtypes of tremor dominant and intermediate (p 0,007). Taking in to account transition of PD patients in different subtypes, at follow-up, SCOPA-AUT has been observed significantly higher in the PIGD group compared (p 0.05) to the other subtypes.

Conclusions:

Conclusion: Our results support that autonomic dysfunction is more severe in the PIGD than other subtypes .