Luca Magistrelli (Italy)
Movement Disorders Centre, Neurology Unit, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy N/AAuthor Of 1 Presentation
SPREAD OF SEGMENTAL/MULTIFOCAL IDIOPATHIC ADULT-ONSET DYSTONIA TO A THIRD BODY SITE, DATA FROM THE ITALIAN DYSTONIA REGISTRY
- Tommaso Ercoli (Italy)
Abstract
Background and Aims:
Adult-onset focal dystonia can spread to involve one, or less frequently, two additional regions of the body (segmental/multifocal dystonia). Several studies indicated that the site of dystonia onset may affect the risk of initial spread. While prior studies have advanced our understanding of spread of focal dystonia to a second body site, no study has fully characterized spread of segmental/multifocal dystonia to a third body site. The aim of the study is to fully characterize the spread of segmental/multifocal dystonia to a third body site in idiopathic adult-onset patients.
Methods:
We retrospectively analyzed data from the Italian Dystonia Registry, including patients with a diagnosis of segmental/multifocal dystonia involving at least two parts of the body or more.
Results:
We identified 340 patients with segmental/multifocal dystonia involving at least two parts of the body. Spread of dystonia to a third body site occurred in 10/99 (10.1%) patients with segmental/multifocal dystonia and in 42/241 (17.4%) patients with focal onset. Patients with focal dystonia onset had a greater tendency to spread, but gender, years of schooling, comorbidity, family history of dystonia/tremor, age at dystonia onset, and disease duration did not affect the risk of spread to a third body site.
Conclusions:
Spread to a third body site seems to occur in a relative low percentage of adult patients who develop idiopathic dystonia in two parts of the body. Neither the site of dystonia onset nor any other relevant demographic/clinical variable affected spread to a third body site in patients with focal onset.