Ralph L. Sacco (United States of America)
Miller School of Medicine, University of Miami NeurologyAuthor Of 2 Presentations
VASCULAR COGNITIVE IMPAIRMENT
- Ralph L. Sacco (United States of America)
VASCULAR COMPONENTS OF COGNITIVE DECLINE
- Ralph L. Sacco (United States of America)
Abstract
Abstract Body
Vascular Components of Cognitive Decline
Ralph L. Sacco, MD, Miami, FL USA
Cognitive Decline and Dementia are rising threats to our aging populations. There are multiple plausible models for pathophysiological relationships between vascular disease and dementia. Threats to brain health comprise a broader range of conditions and clinical outcomes, including stroke, dementia, vascular cognitive impairment, and cognitive aging. Subclinical markers of vascular brain injury detected by MRI (white matter hyperintensities, covert brain infarctions, cerebral microbleeds, perivascular spaces, cortical atrophy) are determinants of stroke, cognitive impairment, and dementia. Reports from the Northern Manhattan Study have demonstrated that multiple vascular risk factors are predictors for stroke, cognitive impairment, and subclinical markers of vascular injury. Key risk factors for stroke include blood pressure, glucose, cholesterol, as well as behaviors such as smoking, physical activity, obesity, and diet and define ideal cardiovascular health. Inflammatory and immune pathways may also be novel determinants of impaired brain health. The broader concept of brain health has resulted in a conceptual shift from vascular risk factors to a multi-dimensional view of the determinants of brain health. Enhanced adherence to the goals recommended by national and international organizations to shift more of the population to ideal cardiovascular health will be necessary to successfully prevent stroke and maintain brain health for our aging populations. Our neurological profession needs to fully embrace the importance of preventive neurology as a critical opportunity to improve the lives of our patients, families and the communities we serve.
Presenter of 2 Presentations
VASCULAR COGNITIVE IMPAIRMENT
- Ralph L. Sacco (United States of America)
VASCULAR COMPONENTS OF COGNITIVE DECLINE
- Ralph L. Sacco (United States of America)
Abstract
Abstract Body
Vascular Components of Cognitive Decline
Ralph L. Sacco, MD, Miami, FL USA
Cognitive Decline and Dementia are rising threats to our aging populations. There are multiple plausible models for pathophysiological relationships between vascular disease and dementia. Threats to brain health comprise a broader range of conditions and clinical outcomes, including stroke, dementia, vascular cognitive impairment, and cognitive aging. Subclinical markers of vascular brain injury detected by MRI (white matter hyperintensities, covert brain infarctions, cerebral microbleeds, perivascular spaces, cortical atrophy) are determinants of stroke, cognitive impairment, and dementia. Reports from the Northern Manhattan Study have demonstrated that multiple vascular risk factors are predictors for stroke, cognitive impairment, and subclinical markers of vascular injury. Key risk factors for stroke include blood pressure, glucose, cholesterol, as well as behaviors such as smoking, physical activity, obesity, and diet and define ideal cardiovascular health. Inflammatory and immune pathways may also be novel determinants of impaired brain health. The broader concept of brain health has resulted in a conceptual shift from vascular risk factors to a multi-dimensional view of the determinants of brain health. Enhanced adherence to the goals recommended by national and international organizations to shift more of the population to ideal cardiovascular health will be necessary to successfully prevent stroke and maintain brain health for our aging populations. Our neurological profession needs to fully embrace the importance of preventive neurology as a critical opportunity to improve the lives of our patients, families and the communities we serve.
Moderator of 1 Session
- Ralph L. Sacco (United States of America)